Leukotriene A4 Hydrolase (LTA4H) Antibody – Rabbit Polyclonal

The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Function: Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. Ref.10 Ref.14 Ref.15 Ref.23 Ref.25 Ref.26 Ref.27

Catalytic activity: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate. Ref.10 Ref.12 Ref.23 Ref.25 Ref.26 Ref.27

Cofactor: Binds 1 zinc ion per subunit. Ref.23 Ref.26 Ref.27

Enzyme regulation: Inhibited by bestatin. Subject to suicide inhibition by leukotriene A4, due to the formation of a covalent adduct at Tyr-379. Ref.12

Pathway: Lipid metabolism; leukotriene B4 biosynthesis.

Subunit structure: Monomer.

Subcellular location: Cytoplasm.

Tissue specificity: Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts.

Post-translational modification: Phosphorylation at Ser-416 inhibits enzymatic activity.

Sequence similarities: Belongs to the peptidase M1 family.