Rabbit Anti-PPP5C Polyclonal Antibody – Cat# MBS416259

PPP5C Antibody – Rabbit Polyclonal

Name: PPP5C Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS416259
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416259

This gene encodes a serine/threonine phosphatase which is a member of the protein phosphatase catalytic subunit family. Proteins in this family participate in pathways regulated by reversible phosphorylation at serine and threonine residues; many of these… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

PPP5C, Polyclonal Antibody

Full Product Name

Anti-PPP5C Antibody

Product Gene Name

anti-PPP5C antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human. Predicted: Mouse, Rat.

Form/Format

Liquid

Purity/Purification

Affinity purified

Concentration

100ug/100ul (lot specific)

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

56,879 Da

OMIM

600658

Storage Buffer

PBS, pH 7.4 with 0.02% Sodium Azide

Immunogen

Rabbit polyclonal PPP5C (1) antibody was raised against a recombinate human PPP5C protein 223-487aa (NM_006247).

Applications Tested/Suitable for anti-PPP5C antibody

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-PPP5C antibody

ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:1,000-1:2,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.

Product References and Citations for anti-PPP5C antibody

(1) Amable,L., Grankvist,N., Largen,J.W. et al. Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1). J. Biol. Chem. 286 (47), 40413-40422 (2011).

Other Notes

Small volumes of anti-PPP5C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPP5C purchase

MBS416259 is an antibody targeting PPP5C. Reactive in Human. Predicted: Mouse, Rat.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PPP5C. It may not necessarily be applicable to this product.

NCBI GI #

38197276

NCBI GeneID

5536

NCBI Accession #

AAH01831.4

UniProt Secondary Accession #

Q16722; Q53XV2

UniProt Related Accession #

P53041

NCBI Official Full Name

PPP5C protein, partial

NCBI Official Synonym Full Names

protein phosphatase 5, catalytic subunit

NCBI Official Symbol

PPP5C

NCBI Official Synonym Symbols

PP5; PPT; PPP5

UniProt Gene Name

PPP5C

UniProt Entry Name

PPP5_HUMAN

NCBI Protein Information

serine/threonine-protein phosphatase 5; PP-T; protein phosphatase T

UniProt Comments for PPP5C

PPP5C: a Ser/Thr phosphatase. Plays a role in the survival of cells in a low oxygen stress by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes apoptosis. Has been reported to interact with DNA-PK, dephosphorylating it at two functional sites. May play a role in the regulation of RNA biogenesis and/or mitosis.

Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: nucleoplasm; neuron projection; cell soma; membrane; intracellular membrane-bound organelle; cytoplasm; nucleus; cytosol

Molecular Function: identical protein binding; signal transducer activity; protein binding; RNA binding; metal ion binding; protein serine/threonine phosphatase activity; lipid binding; phosphoprotein phosphatase activity

Biological Process: mitosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; protein heterooligomerization; response to morphine; signal transduction; protein amino acid dephosphorylation; DNA repair

Research Articles on PPP5C

1. These results demonstrate that Hsp70 recruits PP5 and activates its phosphatase activity which suggests dual roles for PP5 that might link chaperone systems with signaling pathways in cancer and development.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PPP5C antibody

Reference Product	PubMed Publications
RAF1 antibody	>1 publications with PPP5C and RAF1

Pathways associated with anti-PPP5C antibody

Products by Pathway	Pathway Diagram
ErbB1 Downstream Signaling Pathway antibodies	ErbB1 Downstream Signaling Pathway Diagram
Glucocorticoid Receptor Regulatory Network Pathway antibodies	Glucocorticoid Receptor Regulatory Network Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram

Diseases associated with anti-PPP5C antibody

Disease Name	Pubmed Publications
Weight Gain Antibodies	>2 publications with PPP5C and Weight Gain
Carcinoma, Hepatocellular Antibodies	>1 publications with PPP5C and Carcinoma, Hepatocellular
Nervous System Diseases Antibodies	>1 publications with PPP5C and Nervous System Diseases

Organs/Tissues associated with anti-PPP5C antibody

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>2 publications with PPP5C and Embryonic Tissue
Pancreas Antibodies	>1 publications with PPP5C and Pancreas
Blood Antibodies	>1 publications with PPP5C and Blood
Brain Antibodies	>1 publications with PPP5C and Brain