Rabbit Anti-LRRC8A Polyclonal Antibody – Cat# MBS416289

LRRC8A Antibody – Rabbit Polyclonal

Name: LRRC8A Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS416289
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416289

This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This family member is a putative… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

LRRC8A, Polyclonal Antibody

Full Product Name

Anti-LRRC8A Antibody

Product Gene Name

anti-LRRC8A antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human. Predicted: Mouse, Rat

Form/Format

Liquid

Purity/Purification

Affinity purified

Concentration

100ug/100ul (lot specific)

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

94,199 Da

OMIM

608360

Storage Buffer

PBS, pH 7.4 with 0.02% Sodium Azide

Immunogen

Rabbit polyclonal LRRC8A (1) antibody was raised against a recombinated human LRRC8A protein 648-803aa (BC051322).

Applications Tested/Suitable for anti-LRRC8A antibody

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-LRRC8A antibody

ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:500-1:1,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.

Product References and Citations for anti-LRRC8A antibody

(1) Smits,G. and Kajava,A.V. LRRC8 extracellular domain is composed of 17 leucine-rich repeats. Mol. Immunol. 41 (5), 561-562 (2004).

Other Notes

Small volumes of anti-LRRC8A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LRRC8A purchase

MBS416289 is an antibody targeting LRRC8A. Reactive in Human. Predicted: Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LRRC8A. It may not necessarily be applicable to this product.

NCBI GI #

30410929

NCBI GeneID

56262

NCBI Accession #

BC051322

UniProt Secondary Accession #

Q6UXM2; Q8NCI0; Q9P2B1

UniProt Related Accession #

Q8IWT6

NCBI Official Full Name

Homo sapiens leucine rich repeat containing 8 family, member A, mRNA

NCBI Official Synonym Full Names

leucine rich repeat containing 8 family, member A

NCBI Official Symbol

LRRC8A

NCBI Official Synonym Symbols

AGM5; LRRC8; SWELL1

UniProt Protein Name

Volume-regulated anion channel subunit LRRC8A

UniProt Synonym Protein Names

Leucine-rich repeat-containing protein 8A; Swelling protein 1

Protein Family

Volume-regulated anion channel

UniProt Gene Name

LRRC8A

UniProt Entry Name

LRC8A_HUMAN

NCBI Protein Information

volume-regulated anion channel subunit LRRC8A; leucine-rich repeat-containing protein 8A; swelling protein 1

UniProt Comments for LRRC8A

LRRC8A: Involved in B-cell development. Required for the pro-B cell to pre-B cell transition. Defects in LRRC8A are the cause of agammaglobulinemia type 5 (AGM5). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. A chromosomal aberration involving LRRC8 has been found in a patient with congenital agammaglobulinemia. Translocation t(9;20)(q33.2;q12). The translocation truncates the LRRC8 gene, resulting in deletion of the eighth, ninth, and half of the seventh LRR domains.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: cell surface; membrane; plasma membrane

Molecular Function: protein binding; anion channel activity

Biological Process: pre-B cell differentiation; cell volume homeostasis; response to osmotic stress; anion transport

Disease: Agammaglobulinemia 5, Autosomal Dominant

Research Articles on LRRC8A

1. Study identified SWELL1 (LRRC8A), a member of a four-transmembrane protein family with unknown function, as essential for hypotonicity-induced iodide influx. SWELL1 is localized to the plasma membrane, and its knockdown dramatically reduces endogenous volume-regulated anion channel currents and regulatory cell volume decrease in various cell types.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-LRRC8A antibody

Disease Name	Pubmed Publications
Agammaglobulinemia Antibodies	>2 publications with LRRC8A and Agammaglobulinemia
Immune System Diseases Antibodies	>1 publications with LRRC8A and Immune System Diseases
Lung Neoplasms Antibodies	>1 publications with LRRC8A and Lung Neoplasms

Organs/Tissues associated with anti-LRRC8A antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>6 publications with LRRC8A and Blood
Lung Antibodies	>2 publications with LRRC8A and Lung
Nerve Antibodies	>2 publications with LRRC8A and Nerve
Brain Antibodies	>2 publications with LRRC8A and Brain
Thymus Antibodies	>1 publications with LRRC8A and Thymus
Lymph Node Antibodies	>1 publications with LRRC8A and Lymph Node
Bone Antibodies	>1 publications with LRRC8A and Bone
Skin Antibodies	>1 publications with LRRC8A and Skin
Bone Marrow Antibodies	>1 publications with LRRC8A and Bone Marrow
Placenta Antibodies	>1 publications with LRRC8A and Placenta