HYAL2 Antibody – Rabbit Polyclonal

HYAL2: Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R. Belongs to the glycosyl hydrolase 56 family.

Protein type: Hydrolase; Glycan Metabolism - glycosaminoglycan degradation; EC 3.2.1.35; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: microvillus; cell surface; endoplasmic reticulum; lysosome; cytoplasmic membrane-bound vesicle; cytosol; lipid raft; Golgi membrane; anchored to external side of plasma membrane; anchored to plasma membrane; endocytic vesicle; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; plasma membrane; cytoplasmic vesicle

Molecular Function: viral receptor activity; receptor signaling protein tyrosine kinase inhibitor activity; protein binding; enzyme binding; transforming growth factor beta binding; hyaluronic acid binding; hyaluronoglucuronidase activity; receptor tyrosine kinase binding; hyalurononglucosaminidase activity

Biological Process: negative regulation of MAP kinase activity; entry of virus into host cell; glycosaminoglycan metabolic process; pathogenesis; hyaluronan catabolic process; response to antibiotic; glycosaminoglycan catabolic process; viral envelope fusion with host membrane; monocyte activation; kidney development; defense response to virus; negative regulation of protein kinase B signaling cascade; response to virus; multicellular organismal aging; response to reactive oxygen species; positive regulation of protein import into nucleus; skeletal morphogenesis; cartilage development; carbohydrate metabolic process; positive regulation of transcription from RNA polymerase II promoter; hemopoietic progenitor cell differentiation; negative regulation of cell growth; hyaluronan metabolic process; transformation of host cell by virus; positive regulation of inflammatory response