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FDXR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416404

This gene encodes a mitochondrial flavoprotein that initiates electron transport for cytochromes P450 receiving electrons from NADPH. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012] More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
FDXR, Polyclonal Antibody
Full Product Name
Anti-FDXR Antibody
Product Gene Name
anti-FDXR antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human. Predicted: Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
57,370 Da
OMIM
103270
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Rabbit polyclonal FDXR (1) antibody was raised against a recombinated human FDXR protein 264-458aa (BC002960).
Applications Tested/Suitable for anti-FDXR antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-FDXR antibody
ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:500-1:1,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user

Testing Data of anti-FDXR antibody

Rabbit Anti-FDXR Polyclonal Antibody – Cat# MBS416404

Product References and Citations for anti-FDXR antibody

(1) Shi,Y., Ghosh,M., Kovtunovych,G., et al. Both human ferredoxins 1 and 2 and ferredoxin reductase are important for iron-sulfur cluster biogenesis. Biochim. Biophys. Acta 1823 (2), 484-492 (2012).

Other Notes

Small volumes of anti-FDXR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FDXR purchase

MBS416404 is an antibody targeting FDXR. Reactive in Human. Predicted: Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FDXR. It may not necessarily be applicable to this product.

NCBI GI #
12804204
NCBI GeneID
2232
NCBI Accession #
BC002960
UniProt Secondary Accession #
Q13716; Q4PJI0; Q9BU12; B4DDI7; B4DHX5; B4DQQ4; B4DX24; B7Z7G2; E7EQC1
UniProt Related Accession #
P22570
NCBI Official Full Name
Homo sapiens ferredoxin reductase, mRNA
NCBI Official Synonym Full Names
ferredoxin reductase
NCBI Official Symbol
FDXR
NCBI Official Synonym Symbols
ADXR
UniProt Protein Name
NADPH:adrenodoxin oxidoreductase, mitochondrial
UniProt Synonym Protein Names
Ferredoxin--NADP(+) reductase; Ferredoxin reductase
UniProt Gene Name
FDXR
UniProt Entry Name
ADRO_HUMAN
NCBI Protein Information
NADPH:adrenodoxin oxidoreductase, mitochondrial; AR; adrenodoxin reductase; adrenodoxin-NADP(+) reductase; ferredoxin--NADP(+) reductase

UniProt Comments for FDXR

FDXR: Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver. Belongs to the ferredoxin--NADP reductase type 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Mitochondrial; EC 1.18.1.6

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: protein binding; ferredoxin-NADP+ reductase activity; NADPH-adrenodoxin reductase activity

Biological Process: steroid metabolic process; ubiquinone biosynthetic process; cholesterol metabolic process; generation of precursor metabolites and energy; xenobiotic metabolic process; C21-steroid hormone biosynthetic process; sterol metabolic process; steroid biosynthetic process
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Research Articles on FDXR

1. These results indicated that abundant FDXR expression in these steroidogenic cells was maintained through SF-1 binding to the intronic enhancer of the FDXR gene

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FDXR antibody

 Reference Product  PubMed Publications
 FDX1 antibody  >7 publications with FDXR and FDX1
 DDB2 antibody  >5 publications with FDXR and DDB2
 FHIT antibody  >4 publications with FDXR and FHIT
 TP53 antibody  >3 publications with FDXR and TP53

Pathways associated with anti-FDXR antibody

 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway antibodies  Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway Diagram
 Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway antibodies  Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway Diagram
 Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway antibodies  Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway Diagram
 Defective CYP17A1 Causes Adrenal Hyperplasia 5 (AH5) Pathway antibodies  Defective CYP17A1 Causes Adrenal Hyperplasia 5 (AH5) Pathway Diagram
 Defective CYP19A1 Causes Aromatase Excess Syndrome (AEXS) Pathway antibodies  Defective CYP19A1 Causes Aromatase Excess Syndrome (AEXS) Pathway Diagram
 Defective CYP1B1 Causes Glaucoma Pathway antibodies  Defective CYP1B1 Causes Glaucoma Pathway Diagram
 Defective CYP21A2 Causes Adrenal Hyperplasia 3 (AH3) Pathway antibodies  Defective CYP21A2 Causes Adrenal Hyperplasia 3 (AH3) Pathway Diagram
 Defective CYP24A1 Causes Hypercalcemia, Infantile (HCAI) Pathway antibodies  Defective CYP24A1 Causes Hypercalcemia, Infantile (HCAI) Pathway Diagram

Diseases associated with anti-FDXR antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >4 publications with FDXR and Carcinoma
 Lung Neoplasms Antibodies  >3 publications with FDXR and Lung Neoplasms
 Lung Diseases Antibodies  >3 publications with FDXR and Lung Diseases
 Neoplasms, Experimental Antibodies  >3 publications with FDXR and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >2 publications with FDXR and Cardiovascular Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with FDXR and Cell Transformation, Neoplastic
 Hyperplasia Antibodies  >2 publications with FDXR and Hyperplasia
 Inflammation Antibodies  >2 publications with FDXR and Inflammation
 Neoplasm Metastasis Antibodies  >1 publications with FDXR and Neoplasm Metastasis
 Hypertension Antibodies  >1 publications with FDXR and Hypertension

Organs/Tissues associated with anti-FDXR antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with FDXR and Blood
 Lung Antibodies  >4 publications with FDXR and Lung
 Vascular Antibodies  >1 publications with FDXR and Vascular
 Intestine Antibodies  >1 publications with FDXR and Intestine
 Embryonic Tissue Antibodies  >1 publications with FDXR and Embryonic Tissue
 Muscle Antibodies  >1 publications with FDXR and Muscle
 Liver Antibodies  >1 publications with FDXR and Liver
 Kidney Antibodies  >1 publications with FDXR and Kidney
 Ovary Antibodies  >1 publications with FDXR and Ovary
 Pancreas Antibodies  >1 publications with FDXR and Pancreas
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