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IL34 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416411

MBS416411 is an antibody targeting IL34. Reactive in Human. Host: Rabbit. Rabbit polyclonal IL34 More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
IL34, Polyclonal Antibody
Full Product Name
Anti-IL34 Antibody
Product Gene Name
anti-IL34 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
27,354 Da
OMIM
612081
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Raised against a recombinate human IL34 protein 21-242aa (BC029804).
Applications Tested/Suitable for anti-IL34 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-IL34 antibody
ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:500-1:1,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.

Western Blot (WB) of anti-IL34 antibody

Rabbit Anti-IL34 Polyclonal Antibody – Cat# MBS416411

Immunohistochemistry (IHC) #2 of anti-IL34 antibody

Rabbit Anti-IL34 Polyclonal Antibody, Immunohistochemistry (IHC) #2 – Cat# MBS416411

Product References and Citations for anti-IL34 antibody

(1) Wei,S., Nandi,S., Chitu,V., et al. Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells. J. Leukoc. Biol. 88 (3), 495-505 (2010).

Other Notes

Small volumes of anti-IL34 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL34. It may not necessarily be applicable to this product.

NCBI GI #
20987449
NCBI GeneID
146433
NCBI Accession #
BC029804
UniProt Secondary Accession #
Q8N6L2; B2RC28; B2Z4A8; B2ZC70
UniProt Related Accession #
Q6ZMJ4
NCBI Official Full Name
Homo sapiens interleukin 34, mRNA
NCBI Official Synonym Full Names
interleukin 34
NCBI Official Symbol
IL34
NCBI Official Synonym Symbols
IL-34; C16orf77
UniProt Protein Name
Interleukin-34
Protein Family
Interleukin
UniProt Gene Name
IL34
UniProt Entry Name
IL34_HUMAN
NCBI Protein Information
interleukin-34

NCBI Summary for IL34

Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

UniProt Comments for IL34

IL34: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Belongs to the IL-34 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted, signal peptide; Cell cycle regulation; Secreted

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; macrophage colony stimulating factor receptor binding

Biological Process: positive regulation of cell proliferation; innate immune response; positive regulation of protein amino acid phosphorylation; inflammatory response
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Research Articles on IL34

1. IL-34 expression in human gingival fibroblasts, stimulated by TNF-alpha and IL-1beta

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL34 antibody

 Reference Product  PubMed Publications
 CSF1R antibody  >6 publications with IL34 and CSF1R

Diseases associated with anti-IL34 antibody

 Disease Name  Pubmed Publications
 Diabetes Mellitus Antibodies  >1 publications with IL34 and Diabetes Mellitus
 Necrosis Antibodies  >1 publications with IL34 and Necrosis

Organs/Tissues associated with anti-IL34 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >4 publications with IL34 and Bone
 Embryonic Tissue Antibodies  >3 publications with IL34 and Embryonic Tissue
 Brain Antibodies  >2 publications with IL34 and Brain
 Skin Antibodies  >1 publications with IL34 and Skin
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