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IVD Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416535

Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism. The genetic deficiency of IVD results in an accumulation of isovaleric acid, which is toxic to the central nervous system and leads to… More details

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Product Overview

Product Name
IVD, Polyclonal Antibody
Full Product Name
Anti-IVD Antibody
Product Gene Name
anti-IVD antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human. Predicted: Mouse, Rat.
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
42,724 Da
OMIM
243500
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Rabbit polyclonal IVD (1) antibody was raised against a recombinate human IVD protein 188-341aa (BC017202).
Applications Tested/Suitable for anti-IVD antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-IVD antibody
ELISA titer: 1:20,000-1:80,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.

Testing Data of anti-IVD antibody

Rabbit Anti-IVD Polyclonal Antibody – Cat# MBS416535

Product References and Citations for anti-IVD antibody

(1) Lee,H.H., Lee,R.S., Lai,C.K. et al. A novel duplication at the putative DNA polymerase alpha arrest site and a founder mutation in Chinese in the IVD gene underlie isovaleric acidaemia. Hong Kong Med J 16 (3), 219-222 (2010).

Other Notes

Small volumes of anti-IVD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IVD purchase

MBS416535 is an antibody targeting IVD. Reactive in Human. Predicted: Mouse, Rat.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IVD. It may not necessarily be applicable to this product.

NCBI GI #
306897
NCBI GeneID
3712
NCBI Accession #
AAA52711.1
UniProt Secondary Accession #
Q53XZ9; Q96AF6; B2RCV5; B3KVI7; J3KR54
UniProt Related Accession #
P26440
NCBI Official Full Name
isovaleryl-coA dehydrogenase (IVD)
NCBI Official Synonym Full Names
isovaleryl-CoA dehydrogenase
NCBI Official Symbol
IVD
NCBI Official Synonym Symbols
ACAD2
UniProt Protein Name
Isovaleryl-CoA dehydrogenase, mitochondrial
Protein Family
Isovaleryl-CoA dehydrogenase
UniProt Gene Name
IVD
UniProt Entry Name
IVD_HUMAN
NCBI Protein Information
isovaleryl-CoA dehydrogenase, mitochondrial; isovaleryl CoA dehydrogenase; isovaleryl Coenzyme A dehydrogenase

UniProt Comments for IVD

IVD: Defects in IVD are the cause of isovaleric acidemia (IVA). IVA is characterized by retarded psychomotor development, a peculiar odor resembling sweaty feet, an aversion to dietary protein, and pernicious vomiting, leading to acidosis and coma. The acute neonatal form leads to massive metabolic acidosis from the first days of life and rapid death. Belongs to the acyl-CoA dehydrogenase family.

Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.3.8.4; Oxidoreductase; Mitochondrial

Chromosomal Location of Human Ortholog: 15q14-q15

Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix

Molecular Function: isovaleryl-CoA dehydrogenase activity; FAD binding

Biological Process: leucine catabolic process; branched chain family amino acid catabolic process

Disease: Isovaleric Acidemia
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Research Articles on IVD

1. study reports the first Saudi isovaleric acidemia patients from a consanguineous family with a novel transversion (p.G362V) and briefly discuss likely phenotype-genotype correlation of the disease in the Saudi population

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IVD antibody

 Reference Product  PubMed Publications
 BCKDHA antibody  >1 publications with IVD and BCKDHA
 DBT antibody  >1 publications with IVD and DBT

Pathways associated with anti-IVD antibody

 Products by Pathway  Pathway Diagram
 Branched-chain Amino Acid Catabolism Pathway antibodies  Branched-chain Amino Acid Catabolism Pathway Diagram
 Leucine Degradation, Leucine => Acetoacetate + Acetyl-CoA Pathway antibodies  Leucine Degradation, Leucine => Acetoacetate + Acetyl-CoA Pathway Diagram
 Leucine Degradation, Leucine => Acetoacetate + Acetyl-CoA Pathway antibodies  Leucine Degradation, Leucine => Acetoacetate + Acetyl-CoA Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Valine, Leucine And Isoleucine Degradation Pathway antibodies  Valine, Leucine And Isoleucine Degradation Pathway Diagram
 Valine, Leucine And Isoleucine Degradation Pathway antibodies  Valine, Leucine And Isoleucine Degradation Pathway Diagram
 Leucine Degradation Pathway antibodies  Leucine Degradation Pathway Diagram

Diseases associated with anti-IVD antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >86 publications with IVD and Disease Models, Animal
 Death Antibodies  >77 publications with IVD and Death
 Inflammation Antibodies  >76 publications with IVD and Inflammation
 Cardiovascular Diseases Antibodies  >74 publications with IVD and Cardiovascular Diseases
 Necrosis Antibodies  >68 publications with IVD and Necrosis
 Brain Diseases Antibodies  >46 publications with IVD and Brain Diseases
 Heart Diseases Antibodies  >29 publications with IVD and Heart Diseases
 Nerve Degeneration Antibodies  >28 publications with IVD and Nerve Degeneration
 Fibrosis Antibodies  >26 publications with IVD and Fibrosis
 Liver Diseases Antibodies  >19 publications with IVD and Liver Diseases

Organs/Tissues associated with anti-IVD antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >650 publications with IVD and Bone
 Blood Antibodies  >184 publications with IVD and Blood
 Connective Tissue Antibodies  >64 publications with IVD and Connective Tissue
 Brain Antibodies  >55 publications with IVD and Brain
 Nerve Antibodies  >52 publications with IVD and Nerve
 Bone Marrow Antibodies  >46 publications with IVD and Bone Marrow
 Heart Antibodies  >38 publications with IVD and Heart
 Muscle Antibodies  >33 publications with IVD and Muscle
 Embryonic Tissue Antibodies  >33 publications with IVD and Embryonic Tissue
 Liver Antibodies  >28 publications with IVD and Liver
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