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BCL2L2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416553

This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under… More details

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Product Overview

Product Name
BCL2L2, Polyclonal Antibody
Full Product Name
Anti-BCL2L2 Antibody
Product Gene Name
anti-BCL2L2 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human. Predicted: Mouse, Rat.
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
37,171 Da
OMIM
601931
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Rabbit polyclonal BCL2L2 (1) antibody was raised against full length recombinate human BCL2L2 protein (NM_004050.4).
Applications Tested/Suitable for anti-BCL2L2 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-BCL2L2 antibody
ELISA titer: 1:20,000-1:80,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.

Testing Data of anti-BCL2L2 antibody

Rabbit Anti-BCL2L2 Polyclonal Antibody – Cat# MBS416553

Product References and Citations for anti-BCL2L2 antibody

(1) Ku,B., Liang,C., Jung,J.U. et al. Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX. Cell Res. 21 (4), 627-641 (2011).

Other Notes

Small volumes of anti-BCL2L2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCL2L2 purchase

MBS416553 is an antibody targeting BCL2L2. Reactive in Human. Predicted: Mouse, Rat.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BCL2L2. It may not necessarily be applicable to this product.

NCBI GI #
315360668
NCBI GeneID
599
NCBI Accession #
NP_001186768.1
UniProt Secondary Accession #
Q2M3U0; Q5U0H4; A8K0F4
UniProt Related Accession #
Q92843
GenBank Nucleotide #
NM_001199839.1
NCBI Official Full Name
bcl-2-like protein 2
NCBI Official Synonym Full Names
BCL2-like 2
NCBI Official Symbol
BCL2L2
NCBI Official Synonym Symbols
BCLW; BCL-W; PPP1R51; BCL2-L-2
UniProt Protein Name
Bcl-2-like protein 2
UniProt Synonym Protein Names
Apoptosis regulator Bcl-W
Protein Family
Bcl-2-like protein
UniProt Gene Name
BCL2L2
UniProt Entry Name
B2CL2_HUMAN
NCBI Protein Information
bcl-2-like protein 2; apoptosis regulator BCL-W; protein phosphatase 1, regulatory subunit 51

UniProt Comments for BCL2L2

BCL2L2: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. Expressed in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines. Belongs to the Bcl-2 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q11.2-q12

Cellular Component: mitochondrial outer membrane; cytosol

Molecular Function: BH domain binding; protein binding; protein homodimerization activity; protein heterodimerization activity

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; spermatogenesis; Sertoli cell proliferation; negative regulation of apoptosis
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Research Articles on BCL2L2

1. over-expression of miR-195 sensitized resistant cells to DOX and enhanced cell apoptosis activity, all of which can be partly rescued by BCL2L2 siRNA and cDNA expression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BCL2L2 antibody

 Reference Product  PubMed Publications
 BAX antibody  >51 publications with BCL2L2 and BAX
 BAD antibody  >26 publications with BCL2L2 and BAD
 MCL1 antibody  >14 publications with BCL2L2 and MCL1
 BID antibody  >14 publications with BCL2L2 and BID
 TP53 antibody  >7 publications with BCL2L2 and TP53
 BIK antibody  >3 publications with BCL2L2 and BIK
 BBC3 antibody  >3 publications with BCL2L2 and BBC3
 BCL2L11 antibody  >1 publications with BCL2L2 and BCL2L11

Pathways associated with anti-BCL2L2 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram

Diseases associated with anti-BCL2L2 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >11 publications with BCL2L2 and Necrosis
 Liver Neoplasms Antibodies  >9 publications with BCL2L2 and Liver Neoplasms
 Liver Diseases Antibodies  >9 publications with BCL2L2 and Liver Diseases
 Lung Neoplasms Antibodies  >8 publications with BCL2L2 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >7 publications with BCL2L2 and Carcinoma, Hepatocellular
 Glioma Antibodies  >7 publications with BCL2L2 and Glioma
 Disease Models, Animal Antibodies  >7 publications with BCL2L2 and Disease Models, Animal
 Breast Neoplasms Antibodies  >5 publications with BCL2L2 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >5 publications with BCL2L2 and Neoplasms, Experimental
 Nerve Degeneration Antibodies  >4 publications with BCL2L2 and Nerve Degeneration

Organs/Tissues associated with anti-BCL2L2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >28 publications with BCL2L2 and Brain
 Blood Antibodies  >20 publications with BCL2L2 and Blood
 Lung Antibodies  >12 publications with BCL2L2 and Lung
 Testis Antibodies  >12 publications with BCL2L2 and Testis
 Liver Antibodies  >10 publications with BCL2L2 and Liver
 Intestine Antibodies  >10 publications with BCL2L2 and Intestine
 Embryonic Tissue Antibodies  >5 publications with BCL2L2 and Embryonic Tissue
 Stomach Antibodies  >5 publications with BCL2L2 and Stomach
 Vascular Antibodies  >4 publications with BCL2L2 and Vascular
 Muscle Antibodies  >4 publications with BCL2L2 and Muscle
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