ABCB8 Antibody – Rabbit Polyclonal

ABCB8: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes. [provided by RefSeq, Jul 2008]

Protein type: Mitochondrial; Transporter, ABC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral; Hydrolase

Chromosomal Location of Human Ortholog: 7q36

Cellular Component: mitochondrial envelope; mitochondrion; membrane; mitochondrial inner membrane; nucleolus; integral to membrane; ATP-binding cassette (ABC) transporter complex; nucleus

Molecular Function: transporter activity; ATPase activity, coupled to transmembrane movement of substances; ATP binding

Biological Process: transport; metabolic process; transmembrane transport