Rabbit Anti-N-myc Polyclonal Antibody – Cat# MBS416623

N-myc Antibody – Rabbit Polyclonal

Name: N-myc Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS416623
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416623

MBS416623 is an antibody targeting N-myc. Reactive in Human, Mouse. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

N-myc, Polyclonal Antibody

Full Product Name

Anti-N-myc Antibody

Product Gene Name

anti-N-myc antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Liquid

Purity/Purification

Purified

Concentration

100ug/100ul (lot specific)

Specificity

N-Myc antibody detects endogenous levels of N-Myc protein. Not tested with other proteins

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

49,561 Da

OMIM

164280

Storage Buffer

PBS, pH 7.4 with 0.02% Sodium Azide

Immunogen

Synthetic peptide conjugated to KLH

Applications Tested/Suitable for anti-N-myc antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-N-myc antibody

Recommended dilutions:
Peptide ELISA: 1:80,000
WB: 1:500 - 1:1000
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Product References and Citations for anti-N-myc antibody

Prendergast, G.C., Lawe, D., and Ziff, E.B. 1991. Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and Ras cotransformation.

Other Notes

Small volumes of anti-N-myc antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for N-myc. It may not necessarily be applicable to this product.

NCBI GI #

19923312

NCBI GeneID

4613

NCBI Accession #

NP_005369.2

UniProt Secondary Accession #

Q53XS5; Q6LDT9

UniProt Related Accession #

P04198

GenBank Nucleotide #

NM_005378.5

NCBI Official Full Name

N-myc proto-oncogene protein isoform 1

NCBI Official Synonym Full Names

v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog

NCBI Official Symbol

MYCN

NCBI Official Synonym Symbols

NMYC; ODED; MODED; N-myc; bHLHe37

UniProt Protein Name

N-myc proto-oncogene protein

UniProt Synonym Protein Names

Class E basic helix-loop-helix protein 37; bHLHe37

Protein Family

N-myc 2 proto-oncogene protein

UniProt Gene Name

MYCN

UniProt Entry Name

MYCN_HUMAN

NCBI Protein Information

N-myc proto-oncogene protein; class E basic helix-loop-helix protein 37; neuroblastoma MYC oncogene; neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene; oncogene NMYC; pp65/67

NCBI Summary for N-myc

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

UniProt Comments for N-myc

N-Myc: a proto-oncogenic transcription factor. Plays a role in cell proliferation, apoptosis and in the development of human tumors.

Protein type: DNA-binding; Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 2p24.3

Cellular Component: nucleus; chromatin

Molecular Function: protein dimerization activity; protein binding; DNA binding; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; branching morphogenesis of a tube; negative regulation of astrocyte differentiation; positive regulation of mesenchymal cell proliferation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; cartilage condensation; lung development; embryonic skeletal morphogenesis

Disease: Feingold Syndrome 1; Tracheoesophageal Fistula With Or Without Esophageal Atresia

Research Articles on N-myc

1. ASCT2 expression, which correlates with that of N-Myc and ATF4, is markedly elevated in high-stage neuroblastoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-N-myc antibody

Reference Product	PubMed Publications
MAX antibody	>576 publications with N-myc and MAX
MTOR antibody	>130 publications with N-myc and MTOR
SP1 antibody	>111 publications with N-myc and SP1
PTEN antibody	>94 publications with N-myc and PTEN
SHH antibody	>46 publications with N-myc and SHH
TRRAP antibody	>27 publications with N-myc and TRRAP
PAX3 antibody	>18 publications with N-myc and PAX3
NES antibody	>14 publications with N-myc and NES
NMI antibody	>11 publications with N-myc and NMI

Pathways associated with anti-N-myc antibody

Products by Pathway	Pathway Diagram
Transcriptional Misregulation In Cancer Pathway antibodies	Transcriptional Misregulation In Cancer Pathway Diagram
Transcriptional Misregulation In Cancer Pathway antibodies	Transcriptional Misregulation In Cancer Pathway Diagram

Diseases associated with anti-N-myc antibody

Disease Name	Pubmed Publications
Neuroblastoma Antibodies	>1589 publications with N-myc and Neuroblastoma
Cell Transformation, Neoplastic Antibodies	>1045 publications with N-myc and Cell Transformation, Neoplastic
Neoplasms, Experimental Antibodies	>766 publications with N-myc and Neoplasms, Experimental
Adenocarcinoma Antibodies	>640 publications with N-myc and Adenocarcinoma
Breast Neoplasms Antibodies	>589 publications with N-myc and Breast Neoplasms
Disease Models, Animal Antibodies	>553 publications with N-myc and Disease Models, Animal
Nervous System Diseases Antibodies	>430 publications with N-myc and Nervous System Diseases
Liver Neoplasms Antibodies	>390 publications with N-myc and Liver Neoplasms
Liver Diseases Antibodies	>385 publications with N-myc and Liver Diseases
Neoplasm Metastasis Antibodies	>350 publications with N-myc and Neoplasm Metastasis

Organs/Tissues associated with anti-N-myc antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>688 publications with N-myc and Liver
Bone Antibodies	>536 publications with N-myc and Bone
Lung Antibodies	>502 publications with N-myc and Lung
Brain Antibodies	>487 publications with N-myc and Brain
Muscle Antibodies	>415 publications with N-myc and Muscle
Kidney Antibodies	>284 publications with N-myc and Kidney
Embryonic Tissue Antibodies	>262 publications with N-myc and Embryonic Tissue
Heart Antibodies	>180 publications with N-myc and Heart
Eye Antibodies	>98 publications with N-myc and Eye
Thymus Antibodies	>97 publications with N-myc and Thymus