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FBXW8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416697

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs… More details

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Product Overview

Product Name
FBXW8, Polyclonal Antibody
Full Product Name
Anti-FBXW8 Antibody
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
60,705 Da
OMIM
609073
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Synthetic peptide conjugated to KLH
Applications Tested/Suitable for anti-FBXW8 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-FBXW8 antibody
Peptide ELISA titer: 1:160,000
Western blot analysis: 1:200-1000
Optimal dilutions/concentrations should be determined by the end user.

Western Blot (WB) of anti-FBXW8 antibody

Rabbit Anti-FBXW8 Polyclonal Antibody – Cat# MBS416697

Product References and Citations for anti-FBXW8 antibody

Cenciarelli,C.,Chiaur,D.S.,Guardavaccaro,D et,al Identification of a family of human F-box proteins. Curr. Biol. 1999;9 (20),:1177-1179

Other Notes

Small volumes of anti-FBXW8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FBXW8 purchase

MBS416697 is an antibody targeting FBXW8. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FBXW8. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
Homo sapiens F-box and WD repeat domain containing 8 (FBXW8), transcript variant 2, mRNA
NCBI Official Synonym Full Names
F-box and WD repeat domain containing 8
NCBI Official Symbol
FBXW8
NCBI Official Synonym Symbols
FBW6; FBW8; FBX29; FBXW6; FBXO29
UniProt Protein Name
F-box/WD repeat-containing protein 8
UniProt Synonym Protein Names
F-box and WD-40 domain-containing protein 8; F-box only protein 29
UniProt Gene Name
FBXW8
UniProt Entry Name
FBXW8_HUMAN
NCBI Protein Information
F-box/WD repeat-containing protein 8; F-box and WD-40 domain protein 8; F-box and WD-40 domain-containing protein 8; F-box only protein 29

NCBI Summary for FBXW8

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for FBXW8

FBXW8: Substrate-recognition component of a SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Cell development/differentiation

Chromosomal Location of Human Ortholog: 12q24.22

Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; cytoplasm; SCF ubiquitin ligase complex

Molecular Function: protein binding; ubiquitin-protein ligase activity

Biological Process: cell proliferation; protein ubiquitination; positive regulation of dendrite morphogenesis; Golgi organization and biogenesis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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