Rabbit Anti-PLXNB1 Polyclonal Antibody – Cat# MBS416705

Plexin B1 (PLXNB1) Antibody – Rabbit Polyclonal

Name: PLXNB1 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS416705
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416705

Plexins are a family of large, transmembrane receptors for multiple classes of semaphorins in vertebrates. Plexins are widely expressed, and regions of their extracellular domain are homologus to both scatter factor receptors and semaphorin domains. Plexins… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Plexin B1 (PLXNB1), Polyclonal Antibody

Full Product Name

Anti-Plexin B1 Antibody

Product Gene Name

anti-PLXNB1 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Liquid

Purity/Purification

Protein A purified

Concentration

100ug/100ul (lot specific)

Specificity

Plexin B1 antibody detects endogenous levels of Plexin B1 protein. Not tested with other proteins

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

78,395 Da

OMIM

601053

Storage Buffer

PBS, pH 7.4 with 0.02% Sodium Azide

Immunogen

Synthetic peptide conjugated to KLH

Applications Tested/Suitable for anti-PLXNB1 antibody

Peptide ELISA (EIA), Western Blot (WB)

Application Notes for anti-PLXNB1 antibody

Recommended dilutions:
Peptide ELISA: 1:10,000
WB: 1:100 - 1:500
Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Product References and Citations for anti-PLXNB1 antibody

Betti Giusti, Gabriella Fibbi, Francesca Margheri,et,al. A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patients

Other Notes

Small volumes of anti-PLXNB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLXNB1 purchase

MBS416705 is an antibody targeting PLXNB1. Also known as Anti-Plexin B1 Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PLXNB1. It may not necessarily be applicable to this product.

NCBI GI #

194272180

NCBI GeneID

5364

NCBI Accession #

NP_001123554.1

UniProt Secondary Accession #

Q6NY20; Q9UIV7; Q9UJ92; Q9UJ93; A6H8Y2

UniProt Related Accession #

O43157

GenBank Nucleotide #

NM_001130082.2

NCBI Official Full Name

plexin-B1

NCBI Official Synonym Full Names

plexin B1

NCBI Official Symbol

PLXNB1

NCBI Official Synonym Symbols

SEP; PLXN5; PLEXIN-B1

UniProt Protein Name

Plexin-B1

UniProt Synonym Protein Names

Semaphorin receptor SEP

Protein Family

Plexin

UniProt Gene Name

PLXNB1

UniProt Entry Name

PLXB1_HUMAN

NCBI Protein Information

plexin-B1; plexin 5; semaphorin receptor SEP

UniProt Comments for PLXNB1

PLXNB1: Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Belongs to the plexin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; intracellular

Molecular Function: protein binding; transmembrane receptor activity; semaphorin receptor activity; GTPase activating protein binding; receptor activity; semaphorin receptor binding

Biological Process: positive regulation of phosphoinositide 3-kinase cascade; axon guidance; regulation of cell shape; cell migration; negative regulation of osteoblast proliferation; positive regulation of axonogenesis; negative regulation of cell adhesion; signal transduction; neurite morphogenesis; regulation of cytoskeleton organization and biogenesis

Research Articles on PLXNB1

1. The Semaphorin 4D-Plexin-B1-RhoA signaling axis recruits pericytes and regulates vascular permeability through endothelial production of PDGF-B and ANGPTL4.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLXNB1 antibody

Reference Product	PubMed Publications
SEMA4D antibody	>68 publications with PLXNB1 and SEMA4D
MET antibody	>20 publications with PLXNB1 and MET
ERBB2 antibody	>11 publications with PLXNB1 and ERBB2
RND1 antibody	>6 publications with PLXNB1 and RND1
SEMA4A antibody	>3 publications with PLXNB1 and SEMA4A
ARHGEF12 antibody	>3 publications with PLXNB1 and ARHGEF12
ARHGEF11 antibody	>3 publications with PLXNB1 and ARHGEF11
AKT1 antibody	>1 publications with PLXNB1 and AKT1
RAC3 antibody	>1 publications with PLXNB1 and RAC3

Pathways associated with anti-PLXNB1 antibody

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
G Alpha (12/13) Signalling Events Pathway antibodies	G Alpha (12/13) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
Sema4D In Semaphorin Signaling Pathway antibodies	Sema4D In Semaphorin Signaling Pathway Diagram
Sema4D Induced Cell Migration And Growth-cone Collapse Pathway antibodies	Sema4D Induced Cell Migration And Growth-cone Collapse Pathway Diagram
Sema4D Mediated Inhibition Of Cell Attachment And Migration Pathway antibodies	Sema4D Mediated Inhibition Of Cell Attachment And Migration Pathway Diagram
Semaphorin Interactions Pathway antibodies	Semaphorin Interactions Pathway Diagram

Diseases associated with anti-PLXNB1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>3 publications with PLXNB1 and Inflammation
Kidney Diseases Antibodies	>2 publications with PLXNB1 and Kidney Diseases
Necrosis Antibodies	>2 publications with PLXNB1 and Necrosis
Neural Tube Defects Antibodies	>1 publications with PLXNB1 and Neural Tube Defects
Cell Transformation, Neoplastic Antibodies	>1 publications with PLXNB1 and Cell Transformation, Neoplastic
Liver Neoplasms, Experimental Antibodies	>1 publications with PLXNB1 and Liver Neoplasms, Experimental
Liver Diseases Antibodies	>1 publications with PLXNB1 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with PLXNB1 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>1 publications with PLXNB1 and Liver Neoplasms
Hyperplasia Antibodies	>1 publications with PLXNB1 and Hyperplasia

Organs/Tissues associated with anti-PLXNB1 antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>121 publications with PLXNB1 and Nerve
Brain Antibodies	>20 publications with PLXNB1 and Brain
Embryonic Tissue Antibodies	>19 publications with PLXNB1 and Embryonic Tissue
Vascular Antibodies	>14 publications with PLXNB1 and Vascular
Kidney Antibodies	>10 publications with PLXNB1 and Kidney
Bone Antibodies	>10 publications with PLXNB1 and Bone
Skin Antibodies	>7 publications with PLXNB1 and Skin
Lung Antibodies	>6 publications with PLXNB1 and Lung
Lymph Node Antibodies	>6 publications with PLXNB1 and Lymph Node
Prostate Antibodies	>5 publications with PLXNB1 and Prostate