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DUSP16 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416715

This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and… More details

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Testing Data View PDF
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Product Overview

Product Name
DUSP16, Polyclonal Antibody
Full Product Name
Anti-DUSP16 Antibody
Product Gene Name
anti-DUSP16 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human. Predicted: Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
16,078 Da
OMIM
607175
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Rabbit polyclonal DUSP16 (1) antibody was raised against a recombinated human DUSP16 protein 70-249aa (BC109234).
Applications Tested/Suitable for anti-DUSP16 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DUSP16 antibody
ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:1,000-1:2,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.

Testing Data of anti-DUSP16 antibody

Rabbit Anti-DUSP16 Polyclonal Antibody – Cat# MBS416715

Product References and Citations for anti-DUSP16 antibody

(1) Finch,A.R., Caunt,C.J., Perrett,R.M., et al. Dual specificity phosphatases 10 and 16 are positive regulators of EGF-stimulated ERK activity: indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases. Cell. Signal. 24 (5), 1002-1011 (2012).

Other Notes

Small volumes of anti-DUSP16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DUSP16 purchase

MBS416715 is an antibody targeting DUSP16. Reactive in Human. Predicted: Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DUSP16. It may not necessarily be applicable to this product.

NCBI GI #
80475870
NCBI GeneID
80824
NCBI Accession #
BC109234
UniProt Secondary Accession #
Q547C7; Q96QS2; Q9C0G3
UniProt Related Accession #
Q9BY84
NCBI Official Full Name
Homo sapiens dual specificity phosphatase 16, mRNA
NCBI Official Synonym Full Names
dual specificity phosphatase 16
NCBI Official Symbol
DUSP16
NCBI Official Synonym Symbols
MKP7; MKP-7
UniProt Protein Name
Dual specificity protein phosphatase 16
UniProt Synonym Protein Names
Mitogen-activated protein kinase phosphatase 7; MAP kinase phosphatase 7; MKP-7
Protein Family
Dual specificity protein phosphatase
UniProt Gene Name
DUSP16
UniProt Entry Name
DUS16_HUMAN
NCBI Protein Information
dual specificity protein phosphatase 16; MAP kinase phosphatase 7; MAPK phosphatase-7; mitogen-activated protein kinase phosphatase 7

UniProt Comments for DUSP16

MKP-7: a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP16 suppresses MAPK activation in the order of selectivity, JNK >> p38 > ERK, but interacts with ERK as well as JNK and p38. Overexpression of DUSP16 in BCR-ABL-transformed fibroblasts reduces their transforming capacity in vitro and in vivo via down regulation of BCR-ABL-induced JNK activation. DUSP16 might be haploinsufficient for tumor suppression. Contains 1 rhodanese domain.

Protein type: EC 3.1.3.48; Protein phosphatase, dual-specificity; EC 3.1.3.16

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: nucleoplasm; cytoplasmic membrane-bound vesicle; cytoplasm; cytosol; nucleus

Molecular Function: protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity

Biological Process: MAPK export from nucleus; dephosphorylation; MAPK phosphatase export from nucleus, leptomycin B sensitive; protein amino acid dephosphorylation; inactivation of MAPK activity
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Research Articles on DUSP16

1. analysis of the interaction of the MAPK binding domain of DUSP16 with p38alpha

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DUSP16 antibody

 Reference Product  PubMed Publications
 MAPK14 antibody  >2 publications with DUSP16 and MAPK14
 MAPK3 antibody  >1 publications with DUSP16 and MAPK3
 MAPK8 antibody  >1 publications with DUSP16 and MAPK8
 MAPK10 antibody  >1 publications with DUSP16 and MAPK10

Pathways associated with anti-DUSP16 antibody

 Products by Pathway  Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Regulation Of P38-alpha And P38-beta Pathway antibodies  Regulation Of P38-alpha And P38-beta Pathway Diagram

Diseases associated with anti-DUSP16 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >4 publications with DUSP16 and Necrosis
 Inflammation Antibodies  >3 publications with DUSP16 and Inflammation
 Atherosclerosis Antibodies  >2 publications with DUSP16 and Atherosclerosis
 Neoplasm Metastasis Antibodies  >1 publications with DUSP16 and Neoplasm Metastasis
 Cell Transformation, Neoplastic Antibodies  >1 publications with DUSP16 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >1 publications with DUSP16 and Disease Models, Animal
 Lung Neoplasms Antibodies  >1 publications with DUSP16 and Lung Neoplasms

Organs/Tissues associated with anti-DUSP16 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with DUSP16 and Blood
 Kidney Antibodies  >3 publications with DUSP16 and Kidney
 Embryonic Tissue Antibodies  >2 publications with DUSP16 and Embryonic Tissue
 Muscle Antibodies  >2 publications with DUSP16 and Muscle
 Skin Antibodies  >2 publications with DUSP16 and Skin
 Lung Antibodies  >2 publications with DUSP16 and Lung
 Prostate Antibodies  >1 publications with DUSP16 and Prostate
 Liver Antibodies  >1 publications with DUSP16 and Liver
 Lymph Antibodies  >1 publications with DUSP16 and Lymph
 Nerve Antibodies  >1 publications with DUSP16 and Nerve
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