Rabbit Anti-L2HGDH Polyclonal Antibody – Cat# MBS416716

L2HGDH Antibody – Rabbit Polyclonal

Name: L2HGDH Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS416716
Price: 335 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416716

This gene encodes L-2-hydroxyglutarate dehydrogenase, a FAD-dependent enzyme that oxidizes L-2-hydroxyglutarate to alpha-ketoglutarate in a variety of mammalian tissues. Mutations in this gene cause L-2-hydroxyglutaric aciduria, a rare autosomal recessive… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

L2HGDH, Polyclonal Antibody

Full Product Name

Anti-L2HGDH Antibody

Product Gene Name

anti-L2HGDH antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human. Predicted: Mouse, Rat

Form/Format

Liquid

Purity/Purification

Affinity purified

Concentration

100ug/100ul (lot specific)

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

48,505 Da

OMIM

236792

Storage Buffer

PBS, pH 7.4 with 0.02% Sodium Azide

Immunogen

Rabbit polyclonal L2HGDH (1) antibody was raised against a recombinated human L2HGDH protein 65-216aa (BC006117).

Applications Tested/Suitable for anti-L2HGDH antibody

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-L2HGDH antibody

ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:1,000-1:2,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.

Product References and Citations for anti-L2HGDH antibody

(1) Brehmer,S., Pusch,S., Schmieder,K., et al. Mutational analysis of D2HGDH and L2HGDH in brain tumours without IDH1 or IDH2 mutations. Neuropathol. Appl. Neurobiol. 37 (3), 330-332 (2011).

Other Notes

Small volumes of anti-L2HGDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for L2HGDH purchase

MBS416716 is an antibody targeting L2HGDH. Reactive in Human. Predicted: Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for L2HGDH. It may not necessarily be applicable to this product.

NCBI GI #

13543954

NCBI GeneID

79944

NCBI Accession #

BC006117

UniProt Secondary Accession #

Q9BRR1

UniProt Related Accession #

Q9H9P8

NCBI Official Full Name

Homo sapiens L-2-hydroxyglutarate dehydrogenase, mRNA

NCBI Official Synonym Full Names

L-2-hydroxyglutarate dehydrogenase

NCBI Official Symbol

L2HGDH

NCBI Official Synonym Symbols

L2HGA; C14orf160

UniProt Protein Name

L-2-hydroxyglutarate dehydrogenase, mitochondrial

UniProt Synonym Protein Names

Duranin

UniProt Gene Name

L2HGDH

UniProt Entry Name

L2HDH_HUMAN

NCBI Protein Information

L-2-hydroxyglutarate dehydrogenase, mitochondrial; L-alpha-hydroxyglutarate dehydrogenase; alpha-hydroxyglutarate oxidoreductase; alpha-ketoglutarate reductase; duranin

UniProt Comments for L2HGDH

L2HGDH: Defects in L2HGDH are the cause of L-2-hydroxyglutaric aciduria (L2HGA). L2HGA is a rare autosomal recessive disorder clinically characterized by mild psychomotor delay in the first years of life, followed by progressive cerebellar ataxia, dysarthria and moderate to severe mental retardation. Diagnosis is based on the presence of an excess of L-2-hydroxyglutaric acid in urine, blood and cerebrospinal fluid. Belongs to the L2HGDH family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Carbohydrate Metabolism - butanoate; Mitochondrial; EC 1.1.99.2

Chromosomal Location of Human Ortholog: 14q21.3

Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane; integral to mitochondrial inner membrane

Molecular Function: 2-hydroxyglutarate dehydrogenase activity

Biological Process: cellular metabolic process; cellular protein metabolic process; 2-oxoglutarate metabolic process

Disease: L-2-hydroxyglutaric Aciduria

Research Articles on L2HGDH

1. modest increases in intracellular 2-HG in acute myeloid leukaemia cells, as seen with the rs11554137 SNP, might enhance chemoresistance, or promote acquisition of leukaemia-iniating mutations

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-L2HGDH antibody

Reference Product	PubMed Publications
D2HGDH antibody	>2 publications with L2HGDH and D2HGDH

Pathways associated with anti-L2HGDH antibody

Products by Pathway	Pathway Diagram
Butanoate Metabolism Pathway antibodies	Butanoate Metabolism Pathway Diagram
Butanoate Metabolism Pathway antibodies	Butanoate Metabolism Pathway Diagram
Interconversion Of 2-oxoglutarate And 2-hydroxyglutarate Pathway antibodies	Interconversion Of 2-oxoglutarate And 2-hydroxyglutarate Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway antibodies	Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway Diagram
The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway antibodies	The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway Diagram

Diseases associated with anti-L2HGDH antibody

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>20 publications with L2HGDH and Brain Diseases
Nervous System Diseases Antibodies	>19 publications with L2HGDH and Nervous System Diseases
Epilepsy Antibodies	>7 publications with L2HGDH and Epilepsy
2-Hydroxyglutaricaciduria Antibodies	>6 publications with L2HGDH and 2-Hydroxyglutaricaciduria
Seizures Antibodies	>4 publications with L2HGDH and Seizures
Disease Models, Animal Antibodies	>2 publications with L2HGDH and Disease Models, Animal
Cognition Disorders Antibodies	>1 publications with L2HGDH and Cognition Disorders
Intellectual Disability Antibodies	>1 publications with L2HGDH and Intellectual Disability

Organs/Tissues associated with anti-L2HGDH antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>21 publications with L2HGDH and Brain
Blood Antibodies	>6 publications with L2HGDH and Blood
Liver Antibodies	>1 publications with L2HGDH and Liver
Testis Antibodies	>1 publications with L2HGDH and Testis
Embryonic Tissue Antibodies	>1 publications with L2HGDH and Embryonic Tissue
Kidney Antibodies	>1 publications with L2HGDH and Kidney