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ITM2C Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416824

MBS416824 is an antibody targeting ITM2C. Reactive in Human. Predicted: Mouse, Rat.. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
ITM2C, Polyclonal Antibody
Full Product Name
Anti-ITM2C Antibody
Product Gene Name
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human. Predicted: Mouse, Rat.
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
25,921 Da
OMIM
609554
3D Structure
ModBase 3D Structure for Q9NQX7
Storage Buffer
PBS, pH 7.4 with 0.02% Sodium Azide
Immunogen
Rabbit polyclonal ITM2C (1) antibody was raised against a recombinate human ITM2C protein 92-227aa (BC025742).
Applications Tested/Suitable for anti-ITM2C antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-ITM2C antibody
ELISA titer: 1:20,000-1:80,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user.

Testing Data of anti-ITM2C antibody

Rabbit Anti-ITM2C Polyclonal Antibody – Cat# MBS416824

Product References and Citations for anti-ITM2C antibody

(1) Yoshida,T., Kato,K., Yokoi,K. et al. Association of genetic variants with hemorrhagic stroke in Japanese individuals. Int. J. Mol. Med. 25 (4), 649-656 (2010).

Other Notes

Small volumes of anti-ITM2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ITM2C. It may not necessarily be applicable to this product.

NCBI GI #
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
NCBI Official Full Name
ITM2C
UniProt Protein Name
Integral membrane protein 2C
UniProt Synonym Protein Names
Cerebral protein 14; Transmembrane protein BRI3
UniProt Gene Name
ITM2C
UniProt Entry Name
ITM2C_HUMAN

UniProt Comments for ITM2C

ITM2C: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. Belongs to the ITM2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q37

Cellular Component: Golgi apparatus; lysosomal membrane; perinuclear region of cytoplasm; lysosome; plasma membrane; integral to membrane

Molecular Function: protein binding; beta-amyloid binding; ATP binding

Biological Process: neuron differentiation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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