USP22 Antibody – Rabbit Polyclonal

USP22: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression. Belongs to the peptidase C19 family. UBP8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Ubiquitin-specific protease; EC 3.4.19.12; Nuclear receptor co-regulator; Ubiquitin conjugating system; Transcription, coactivator/corepressor; Protease

Chromosomal Location of Human Ortholog: 17p11.2

Molecular Function: protein binding; H4 histone acetyltransferase activity; enzyme binding; ligand-dependent nuclear receptor transcription coactivator activity; zinc ion binding; cysteine-type endopeptidase activity; transcription coactivator activity; ubiquitin-specific protease activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; embryonic development; establishment and/or maintenance of chromatin architecture; protein deubiquitination; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; histone ubiquitination; positive regulation of mitotic cell cycle; cell cycle; histone deubiquitination