GAPDH Antibody – Mouse Monoclonal

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Shintani-ishida, K et al. "MDMA induces cardiac contractile dysfunction through autophagy upregulation and lysosome destabilization in rats." Biochim. Biophys. Acta 1842:691-700 (2014). PubMed: 24491919.
Cicchetti, F et al. "Mutant huntingtin is present in neuronal grafts in Huntington's disease patients." Ann. Neurol. : (2014). PubMed: 24798518.
Shintani-ishida, K et al. "MDMA induces cardiac contractile dysfunction through autophagy upregulation and lysosome." Biochim. Biophys. Acta, Mol. Basis. Dis. 5:691-700 (2014). PubMed: 24491919.
Cicchetti, F et al. "Mutant huntingtin is present in neuronal grafts in huntington disease patients." Ann. Neurol. 1:31-42 (2014). PubMed: 24798518.
Smith, GS et al. "Nucleus-localized 21.5-kDa myelin basic protein promotes oligodendrocyte proliferation and enhances neurite outgrowth in coculture, unlike the plasma membrane-associated 18.5-kDa isoform." J Neurosci Res. 91 (3):349-362 (2013). DOI: 10.1002/jnr.23166. PubMed: 23184356. Application: Western Blot.
New, LA et al. " Direct Regulation of Nephrin Tyrosine Phosphorylation by Nck Adaptor Proteins." J Biol Chem 288 (3):1500-1510 (2013). DOI: 10.1074/jbc.M112.439463. Application: Western Blot.
Bryand, KF et al. "Identification of a divalent metal cation binding site in herpes simplex virus 1 (HSV-1) ICP8 required for HSV replication." J Virol 86 (12):6825-6834 (2012). DOI: 10.1128/JVI.00374-12. Application: Immunoblot.
Evans, RP et al. "Expression, adverse prognostic significance and therapeutic small molecule inhibition of Polo-like kinase 1 in multiple myeloma." Leuk Res 35 (12):1637-1640 (2011). DOI: 10.1016/j.leukres.2011.07.016. PubMed: 21816470. Application: Immunoblot.
Evans, RP et al. "The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment for multiple myeloma." Br J Haematol 140 (3):295-302 (2008). PubMed: 18076711. Application: Immunoblot.
Evans, RP et al. "Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells." Leuk Lymphoma 49 (3):559-569 (2008). DOI: 10.1080/10428190701824544. Application: Immunoblot.

Small volumes of anti-GAPDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS416879 is an antibody targeting GAPDH. Host: Mouse.