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eIF4B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS416912

MBS416912 is an antibody targeting eIF4B. Reactive in Human, Mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
eIF4B, Polyclonal Antibody
Full Product Name
Anti-eIF4B Antibody
Product Gene Name
anti-eIF4B antibody
Product Synonym Names
Anti-eIF4B (phospho-Ser422) Antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Specificity
eIF4B (phospho-Ser422) Antibody detects endogenous levels of eIF4B only when phosphorylated at Serine 422.
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
64,805 Da
OMIM
603928
Storage Buffer
Rabbit IgG in phosphate buffered saline (without Mg< sup>2< /sup>+ and Ca< sup>2< /sup>+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antibody was produced against synthesized phosphopeptide derived from human eIF4B around the phosphorylation site of Serine 422 (T-G-SP-E-S).
Applications Tested/Suitable for anti-eIF4B antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-eIF4B antibody
WB: 1:500~1000
IHC: 1:50~100

Testing Data of anti-eIF4B antibody

Rabbit Anti-eIF4B Polyclonal Antibody – Cat# MBS416912

Other Notes

Small volumes of anti-eIF4B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for eIF4B. It may not necessarily be applicable to this product.

NCBI GI #
50053795
NCBI GeneID
1975
NCBI Accession #
NP_001408.2
UniProt Secondary Accession #
Q4G0E3; Q53HQ2; Q6GPH5; Q6IB46; Q8WYK5; B4DS13
UniProt Related Accession #
P23588
GenBank Nucleotide #
NM_001417.5
NCBI Official Full Name
eukaryotic translation initiation factor 4B isoform 2
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 4B
NCBI Official Symbol
EIF4B
NCBI Official Synonym Symbols
EIF-4B; PRO1843
UniProt Protein Name
Eukaryotic translation initiation factor 4B
Protein Family
Eukaryotic translation initiation factor
UniProt Gene Name
EIF4B
UniProt Entry Name
IF4B_HUMAN
NCBI Protein Information
eukaryotic translation initiation factor 4B

UniProt Comments for eIF4B

EIF4B: eukaryotic translation initiation factor 4B. Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.

Protein type: Translation initiation; RNA-binding; Translation

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: eukaryotic translation initiation factor 4F complex; cytosol

Molecular Function: protein binding; RNA binding; translation initiation factor activity; nucleotide binding

Biological Process: poly(A) tail shortening; cellular protein metabolic process; translation; insulin receptor signaling pathway; translational initiation; gene expression; regulation of translational initiation; mRNA catabolic process, deadenylation-dependent decay
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Research Articles on eIF4B

1. eIF4B is the RSK downstream effector responsible for elevated Lamgamma2 as well as MYC protein in neoplastic epithelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-eIF4B antibody

 Reference Product  PubMed Publications
 EIF4E antibody  >53 publications with eIF4B and EIF4E
 EIF4G1 antibody  >10 publications with eIF4B and EIF4G1
 EIF5 antibody  >6 publications with eIF4B and EIF5
 EIF3G antibody  >2 publications with eIF4B and EIF3G
 EIF3B antibody  >2 publications with eIF4B and EIF3B
 PABPC1 antibody  >1 publications with eIF4B and PABPC1
 RPS6KB1 antibody  >1 publications with eIF4B and RPS6KB1

Pathways associated with anti-eIF4B antibody

 Products by Pathway  Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway antibodies  GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 IGF1R Signaling Cascade Pathway antibodies  IGF1R Signaling Cascade Pathway Diagram
 IRS-mediated Signalling Pathway antibodies  IRS-mediated Signalling Pathway Diagram
 IRS-related Events Pathway antibodies  IRS-related Events Pathway Diagram

Diseases associated with anti-eIF4B antibody

 Disease Name  Pubmed Publications
 Cell Transformation, Neoplastic Antibodies  >8 publications with eIF4B and Cell Transformation, Neoplastic
 Necrosis Antibodies  >8 publications with eIF4B and Necrosis
 Disease Models, Animal Antibodies  >4 publications with eIF4B and Disease Models, Animal
 Neoplasm Invasiveness Antibodies  >4 publications with eIF4B and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >3 publications with eIF4B and Neoplasm Metastasis
 Kidney Diseases Antibodies  >3 publications with eIF4B and Kidney Diseases
 Weight Loss Antibodies  >2 publications with eIF4B and Weight Loss
 Cardiovascular Diseases Antibodies  >2 publications with eIF4B and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >2 publications with eIF4B and Neoplasms, Experimental
 Atherosclerosis Antibodies  >1 publications with eIF4B and Atherosclerosis

Organs/Tissues associated with anti-eIF4B antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >39 publications with eIF4B and Blood
 Mouth Antibodies  >12 publications with eIF4B and Mouth
 Liver Antibodies  >11 publications with eIF4B and Liver
 Muscle Antibodies  >8 publications with eIF4B and Muscle
 Lung Antibodies  >7 publications with eIF4B and Lung
 Vascular Antibodies  >6 publications with eIF4B and Vascular
 Brain Antibodies  >6 publications with eIF4B and Brain
 Prostate Antibodies  >4 publications with eIF4B and Prostate
 Kidney Antibodies  >3 publications with eIF4B and Kidney
 Skin Antibodies  >3 publications with eIF4B and Skin
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