PKCdelta Antibody – Rabbit Polyclonal

PKCD: an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities.

Protein type: Protein kinase, AGC; Nuclear receptor co-regulator; Tumor suppressor; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.13; AGC group; PKC family; Delta subfamily

Cellular Component: nuclear matrix; mitochondrion; membrane; endoplasmic reticulum; cytoplasm; plasma membrane; intercellular junction; cytosol; nucleus

Molecular Function: protein kinase C activity; metal ion binding; enzyme activator activity; nucleotide binding; non-membrane spanning protein tyrosine kinase activity; protein kinase binding; protein kinase activity; transferase activity; protein serine/threonine kinase activity; calcium-independent protein kinase C activity; enzyme binding; insulin receptor substrate binding; transferase activity, transferring phosphorus-containing groups; kinase activity; ATP binding

Biological Process: B cell proliferation; negative regulation of MAP kinase activity; interleukin-12 production; apoptosis; positive regulation of apoptosis; protein amino acid autophosphorylation; negative regulation of insulin receptor signaling pathway; protein amino acid phosphorylation; positive regulation of protein amino acid dephosphorylation; negative regulation of filopodium formation; positive regulation of glucose import; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of superoxide release; negative regulation of peptidyl-tyrosine phosphorylation; neutrophil activation; collagen metabolic process; negative regulation of actin filament polymerization; peptidyl-threonine phosphorylation; aspartate transport; cell cycle; defense response to bacterium; interleukin-10 production; response to oxidative stress; immunoglobulin mediated immune response; phosphorylation