Rabbit Anti-IKB-epsilon Polyclonal Antibody – Cat# MBS417070

IKB-epsilon Antibody – Rabbit Polyclonal

Name: IKB-epsilon Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS417070
Price: 510 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS417070

MBS417070 is an antibody targeting IKB-epsilon. Reactive in Human, Mouse. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

IKB-epsilon, Polyclonal Antibody

Full Product Name

Anti-IKB-epsilon Antibody

Product Gene Name

anti-IKB-epsilon antibody

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Liquid

Purity/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation

Concentration

1ug/ul (lot specific)

Specificity

IkB-epsilon (Phospho-Ser22) antibody detects endogenous levels of IkB-epsilon only when phosphorylated at serine 22.

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

39,200 Da

Storage Buffer

phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human IkB-epsilon around the phosphorylation site of serine 22 (I-E-SP-L-R).

Applications Tested/Suitable for anti-IKB-epsilon antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-IKB-epsilon antibody

WB: 1:500~1:1000
IHC: 1:50~1:100

Other Notes

Small volumes of anti-IKB-epsilon antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IKB-epsilon. It may not necessarily be applicable to this product.

NCBI GI #

2739158

NCBI GeneID

18037

NCBI Accession #

AAB97517.1

UniProt Secondary Accession #

Q3U686; Q9CZZ9; Q9D7U3

UniProt Related Accession #

O54910

NCBI Official Full Name

IkB epsilon

NCBI Official Synonym Full Names

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon

NCBI Official Symbol

Nfkbie

NCBI Official Synonym Symbols

IKBE; IkB-E; ikB-epsilon; NF-kappa-BIE; I-kappa-B-epsilon

UniProt Protein Name

NF-kappa-B inhibitor epsilon

UniProt Synonym Protein Names

I-kappa-B-epsilon; IkB-E; IkB-epsilon; IkappaBepsilon

Protein Family

NF-kappa-B inhibitor

UniProt Gene Name

Nfkbie

UniProt Entry Name

IKBE_MOUSE

NCBI Protein Information

NF-kappa-B inhibitor epsilon; ikappaBepsilon; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

UniProt Comments for IKB-epsilon

IkB-epsilon: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes. Interacts with RELA, REL, NFKB1 nuclear factor NF-kappa-B p50 subunit and NFKB2 nuclear factor NF-kappa-B p52 subunit. Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages. Belongs to the NF-kappa-B inhibitor family.

Protein type: Inhibitor; DNA-binding

Cellular Component: Golgi apparatus; perinuclear region of cytoplasm; cytoplasm

Molecular Function: protein binding

Biological Process: negative regulation of transcription, DNA-dependent; D-serine transport

Research Articles on IKB-epsilon

1. The data imply that regulation of these c-Rel-dependent lymphoid responses is a non-redundant function of IkappaBepsilon.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-IKB-epsilon antibody

Products by Pathway	Pathway Diagram
Activation Of NF-kappaB In B Cells Pathway antibodies	Activation Of NF-kappaB In B Cells Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptosis Signaling Pathway antibodies	Apoptosis Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies	Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Epstein-Barr Virus Infection Pathway antibodies	Epstein-Barr Virus Infection Pathway Diagram

Diseases associated with anti-IKB-epsilon antibody

Disease Name	Pubmed Publications
Necrosis Antibodies	>14 publications with IKB-epsilon and Necrosis
Inflammation Antibodies	>10 publications with IKB-epsilon and Inflammation
Arthritis, Rheumatoid Antibodies	>5 publications with IKB-epsilon and Arthritis, Rheumatoid
Lung Diseases Antibodies	>3 publications with IKB-epsilon and Lung Diseases
Kidney Diseases Antibodies	>2 publications with IKB-epsilon and Kidney Diseases
Cell Transformation, Neoplastic Antibodies	>1 publications with IKB-epsilon and Cell Transformation, Neoplastic
Atherosclerosis Antibodies	>1 publications with IKB-epsilon and Atherosclerosis
Pneumonia Antibodies	>1 publications with IKB-epsilon and Pneumonia
Edema Antibodies	>1 publications with IKB-epsilon and Edema

Organs/Tissues associated with anti-IKB-epsilon antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>11 publications with IKB-epsilon and Blood
Spleen Antibodies	>4 publications with IKB-epsilon and Spleen
Intestine Antibodies	>3 publications with IKB-epsilon and Intestine
Bone Marrow Antibodies	>3 publications with IKB-epsilon and Bone Marrow
Joint Antibodies	>2 publications with IKB-epsilon and Joint
Skin Antibodies	>1 publications with IKB-epsilon and Skin
Lymph Node Antibodies	>1 publications with IKB-epsilon and Lymph Node
Brain Antibodies	>1 publications with IKB-epsilon and Brain
Thymus Antibodies	>1 publications with IKB-epsilon and Thymus