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LPIN1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS417210

This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is… More details

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Product Overview

Product Name
LPIN1, Polyclonal Antibody
Full Product Name
Anti-LPIN1 Antibody
Product Gene Name
anti-LPIN1 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human. Predicted: Mouse, Rat. Not yet tested in other species.
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
98,496 Da
Storage Buffer
PBS, pH 7.4 with 0.02% sodium azide.
Immunogen
Rabbit polyclonal LPIN1 (1) antibody was raised against a recombinate human LPIN1 protein 667-889aa (BC030537).
Applications Tested/Suitable for anti-LPIN1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-LPIN1 antibody
ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:200-1:1,000
Optimal dilutions/concentrations should be determined by the end user

Product References and Citations for anti-LPIN1 antibody

(1) Zhang,R., Jiang,F., Hu,C., et al. Genetic variants of LPIN1 indicate an association with Type 2 diabetes mellitus in a Chinese population. Diabet. Med. 30 (1), 118-122 (2013)

Other Notes

Small volumes of anti-LPIN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LPIN1 purchase

MBS417210 is an antibody targeting LPIN1. Reactive in Human. Predicted: Mouse, Rat. Not yet tested in other species.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LPIN1. It may not necessarily be applicable to this product.

NCBI GI #
7264655
NCBI GeneID
14245
NCBI Accession #
AAF44296.1
UniProt Secondary Accession #
Q9CQI2; Q9JLG6
UniProt Related Accession #
Q91ZP3
NCBI Official Full Name
Lpin1
NCBI Official Synonym Full Names
lipin 1
NCBI Official Symbol
Lpin1
NCBI Official Synonym Symbols
fld; Lipin1; Kiaa0188; mKIAA0188; 4631420P06
UniProt Protein Name
Phosphatidate phosphatase LPIN1
UniProt Synonym Protein Names
Fatty liver dystrophy protein; Lipin-1
Protein Family
Phosphatidate phosphatase
UniProt Gene Name
Lpin1
UniProt Entry Name
LPIN1_MOUSE
NCBI Protein Information
phosphatidate phosphatase LPIN1; fatty liver dystrophy protein; lipin-1

UniProt Comments for LPIN1

LPIN1: Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol. Interacts (via LXXIL motif) with PPARA. Interacts with PPARGC1A. Interaction with PPARA and PPARGC1A leads to the formation of a complex that modulates gene transcription. Interacts with MEF2C. Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract. Inhibited by N-ethylmaleimide. Belongs to the lipin family.

Protein type: EC 3.1.3.4; Phosphatase, lipid

Cellular Component: mitochondrial outer membrane; transcription factor complex; nuclear membrane; mitochondrion; membrane; endoplasmic reticulum; cytoplasm; nucleus

Molecular Function: protein binding; peroxisome proliferator activated receptor binding; hydrolase activity; phosphatidate phosphatase activity; histone deacetylase binding; transcription coactivator activity

Biological Process: fat cell differentiation; mitochondrial fission; transcription, DNA-dependent; regulation of fat cell differentiation; triacylglycerol biosynthetic process; fatty acid catabolic process; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; positive regulation of histone deacetylation; cellular response to insulin stimulus; regulation of transcription, DNA-dependent; dephosphorylation; actin cytoskeleton reorganization; ruffle organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; lipid metabolic process; triacylglycerol mobilization
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Research Articles on LPIN1

1. The findings demonstrate an unanticipated role for lipin-1 as a mediator of macrophage proinflammatory activation and support a critical link between lipid biosynthesis and systemic inflammatory responses.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-LPIN1 antibody

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Depolymerisation Of The Nuclear Lamina Pathway antibodies  Depolymerisation Of The Nuclear Lamina Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram

Diseases associated with anti-LPIN1 antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >42 publications with LPIN1 and Fatty Liver
 Liver Diseases Antibodies  >24 publications with LPIN1 and Liver Diseases
 Inflammation Antibodies  >18 publications with LPIN1 and Inflammation
 Necrosis Antibodies  >7 publications with LPIN1 and Necrosis
 Hyperglycemia Antibodies  >5 publications with LPIN1 and Hyperglycemia
 Nervous System Diseases Antibodies  >5 publications with LPIN1 and Nervous System Diseases
 Weight Loss Antibodies  >5 publications with LPIN1 and Weight Loss
 Disease Models, Animal Antibodies  >4 publications with LPIN1 and Disease Models, Animal
 Fibrosis Antibodies  >3 publications with LPIN1 and Fibrosis
 Hypertension Antibodies  >3 publications with LPIN1 and Hypertension

Organs/Tissues associated with anti-LPIN1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >72 publications with LPIN1 and Liver
 Muscle Antibodies  >33 publications with LPIN1 and Muscle
 Connective Tissue Antibodies  >32 publications with LPIN1 and Connective Tissue
 Blood Antibodies  >27 publications with LPIN1 and Blood
 Heart Antibodies  >11 publications with LPIN1 and Heart
 Brain Antibodies  >10 publications with LPIN1 and Brain
 Kidney Antibodies  >6 publications with LPIN1 and Kidney
 Embryonic Tissue Antibodies  >5 publications with LPIN1 and Embryonic Tissue
 Lung Antibodies  >4 publications with LPIN1 and Lung
 Ovary Antibodies  >4 publications with LPIN1 and Ovary
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