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PRIM2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS417363

This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to… More details

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Product Overview

Product Name
PRIM2, Polyclonal Antibody
Full Product Name
Anti-PRIM2 Antibody
Product Gene Name
anti-PRIM2 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human. Predicted: Mouse, Rat. Not yet tested in other species.
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
19,144 Da
OMIM
176636
Storage Buffer
PBS, pH 7.4 with 0.02% sodium azide.
Immunogen
Rabbit polyclonal PRIM2 (1) antibody was raised against a recombinate human PRIM2 protein 31-170aa (BC064931).
Applications Tested/Suitable for anti-PRIM2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-PRIM2 antibody
ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:200-1:1,000
Optimal dilutions/concentrations should be determined by the end user

Product References and Citations for anti-PRIM2 antibody

(1) Chung,J., Tsai,S., James,A.H. et al. Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells. Epigenetics 7 (5), 429-431 (2012)

Other Notes

Small volumes of anti-PRIM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRIM2 purchase

MBS417363 is an antibody targeting PRIM2. Reactive in Human. Predicted: Mouse, Rat. Not yet tested in other species.. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRIM2. It may not necessarily be applicable to this product.

NCBI GI #
40675621
NCBI GeneID
5558
NCBI Accession #
BC064931
UniProt Secondary Accession #
Q53FJ8; Q6P1Q7; Q8WVL2; Q9H413
UniProt Related Accession #
P49643
NCBI Official Full Name
Homo sapiens primase, DNA, polypeptide 2 (58kDa), mRNA
NCBI Official Synonym Full Names
primase, DNA, polypeptide 2 (58kDa)
NCBI Official Symbol
PRIM2
NCBI Official Synonym Symbols
p58; PRIM2A
UniProt Protein Name
DNA primase large subunit
UniProt Synonym Protein Names
DNA primase 58 kDa subunit; p58
UniProt Gene Name
PRIM2
UniProt Entry Name
PRI2_HUMAN
NCBI Protein Information
DNA primase large subunit; DNA primase 58 kDa subunit

UniProt Comments for PRIM2

PRI2: synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The replication of DNA is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components.

Protein type: Nucleotide Metabolism - pyrimidine; Transferase; Nucleotide Metabolism - purine; EC 2.7.7.-

Chromosomal Location of Human Ortholog: 6p12-p11.1

Cellular Component: nucleoplasm

Molecular Function: DNA binding; DNA primase activity; 4 iron, 4 sulfur cluster binding; metal ion binding

Biological Process: telomere maintenance via semi-conservative replication; DNA replication initiation; telomere maintenance via recombination; DNA replication, synthesis of RNA primer; DNA strand elongation during DNA replication; mitotic cell cycle; telomere maintenance; G1/S transition of mitotic cell cycle
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Research Articles on PRIM2

1. the N-terminal domain of the large subunit of primase (p58N) directly interacts with the C-terminal domain of the catalytic subunit of polalpha (p180C)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRIM2 antibody

 Reference Product  PubMed Publications
 PRIM1 antibody  >3 publications with PRIM2 and PRIM1
 RFC4 antibody  >1 publications with PRIM2 and RFC4
 MCM3 antibody  >1 publications with PRIM2 and MCM3
 POLA1 antibody  >1 publications with PRIM2 and POLA1

Pathways associated with anti-PRIM2 antibody

 Products by Pathway  Pathway Diagram
 Activation Of The Pre-replicative Complex Pathway antibodies  Activation Of The Pre-replicative Complex Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 DNA Replication Pre-Initiation Pathway antibodies  DNA Replication Pre-Initiation Pathway Diagram
 DNA Polymerase Alpha / Primase Complex Pathway antibodies  DNA Polymerase Alpha / Primase Complex Pathway Diagram
 DNA Polymerase Alpha / Primase Complex Pathway antibodies  DNA Polymerase Alpha / Primase Complex Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram

Diseases associated with anti-PRIM2 antibody

 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >1 publications with PRIM2 and Neoplasms, Experimental

Organs/Tissues associated with anti-PRIM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with PRIM2 and Blood
 Placenta Antibodies  >1 publications with PRIM2 and Placenta
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