VprBP Antibody – Rabbit Polyclonal

VPRBP: Component of the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex, VprBP/DCAF1 may function as the substrate recognition module within this complex. For example, VprBP/DCAF1 targets NF2 to the E3 ubiquitin-ligase complex for ubiquitination and subsequent proteasome-dependent degradation. In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1 function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1 function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. Associated with chromatin in a DDB1-independent and cell cycle-dependent manner, VprBP/DCAF1 is recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis. Belongs to the VPRBP/DCAF1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.11.1; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: signalosome; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; ATP binding

Biological Process: V(D)J recombination; transcription, DNA-dependent; viral reproduction; B cell differentiation; cell competition in a multicellular organism; protein ubiquitination; negative regulation of transcription from RNA polymerase II promoter