FBXW11 Antibody – Rabbit Polyclonal

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons. [provided by RefSeq, Jul 2008]

FBW1B: a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex May participate in Wnt signaling. Three alternatively spliced isoforms have been described.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: centrosome; SCF ubiquitin ligase complex; nucleus; cytosol; ubiquitin ligase complex

Molecular Function: protein dimerization activity; protein binding; ubiquitin-protein ligase activity

Biological Process: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; Wnt receptor signaling pathway; protein polyubiquitination; protein destabilization; positive regulation of proteolysis; positive regulation of transcription, DNA-dependent; rhythmic process; protein ubiquitination; negative regulation of NF-kappaB import into nucleus; positive regulation of circadian rhythm; protein amino acid dephosphorylation; mitotic cell cycle; negative regulation of transcription, DNA-dependent; G2/M transition of mitotic cell cycle