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FCRL5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9606269

Function: May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.Similarity: Contains 2 copies of a cytoplasmic motif that… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
FCRL5, Polyclonal Antibody
Full Product Name
FCRL5 Antibody
Product Gene Name
anti-FCRL5 antibody
Product Synonym Names
BXMAS1; CD307 antigen; CD307e; Fc receptor homolog 5; Fc receptor like 5; Fc receptor-like protein 5; FcR-like protein 5; FcRH5; FcRL5; FCRL5_HUMAN; Immune receptor translocation-associated protein 2; Immunoglobulin receptor translocation associated gene 2 protein; Immunoglobulin superfamily receptor translocation associated gene 2 protein; IRTA2; UNQ503/PRO820
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
FCRL5 antibody detects endogenous levels of total FCRL5
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
FCRL5 peptide (MBS9624986) is used for blocking the activity of FCRL5 antibody (MBS9606269)
Molecular Weight
Observed: 107 kD
Predicted: 107 kDa
3D Structure
ModBase 3D Structure for Q96RD9
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide
Subcellular Location
Cell Membrane
Tissue Specificity
Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level).
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-FCRL5 antibody
Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)
Application Notes for anti-FCRL5 antibody
WB: 1:500-1:1000
IF/ICC: 1:100-1:500

Western Blot (WB) of anti-FCRL5 antibody

Western blot analysis of extracts from Jurkat cells, using FCRL5 antibody.
Rabbit Anti-FCRL5 Polyclonal Antibody – Cat# MBS9606269

Immunofluorescene (IF) of anti-FCRL5 antibody

MBS9606269 staining Hela by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Rabbit Anti-FCRL5 Polyclonal Antibody, Immunofluorescene (IF) – Cat# MBS9606269

Other Notes

Small volumes of anti-FCRL5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FCRL5 purchase

MBS9606269 is an antibody targeting FCRL5. Also known as FCRL5 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FCRL5. It may not necessarily be applicable to this product.

NCBI GI #
306035194
NCBI GeneID
83416
NCBI Accession #
NP_001182317.1
UniProt Primary Accession #
Q96RD9
UniProt Secondary Accession #
Q495Q2; Q495Q4; Q5VYK9; Q6UY46; A0N0M2; B7WNT9; B7WP94
UniProt Related Accession #
Q96RD9
GenBank Nucleotide #
NM_001195388.1
NCBI Official Full Name
Fc receptor-like protein 5 isoform 2
NCBI Official Synonym Full Names
Fc receptor like 5
NCBI Official Symbol
FCRL5
NCBI Official Synonym Symbols
CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820
UniProt Protein Name
Fc receptor-like protein 5
UniProt Synonym Protein Names
BXMAS1; Fc receptor homolog 5; FcRH5; Immune receptor translocation-associated protein 2; CD_antigen: CD307e
Protein Family
Fc receptor-like protein
UniProt Gene Name
FCRL5
UniProt Synonym Gene Names
FCRH5; IRTA2; FcR-like protein 5; FcRL5; FcRH5
NCBI Protein Information
Fc receptor-like protein 5

NCBI Summary for FCRL5

This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
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UniProt Comments for FCRL5

May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells.

Research Articles on FCRL5

1. based on FCRL5 binding, we can discern distinct changes in the IgG2 molecule, including the disulfide isoform structure and charge variants related to deamidation. Since both IgG2 deamidation and conversion of disulfide isoforms occur in vivo, these findings elucidate the biological FCRL5 ligand.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-FCRL5 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >7 publications with FCRL5 and Neoplasms
 Bone Diseases Antibodies  >2 publications with FCRL5 and Bone Diseases
 Necrosis Antibodies  >1 publications with FCRL5 and Necrosis
 Thyroid Diseases Antibodies  >1 publications with FCRL5 and Thyroid Diseases
 Cardiovascular Diseases Antibodies  >1 publications with FCRL5 and Cardiovascular Diseases

Organs/Tissues associated with anti-FCRL5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with FCRL5 and Blood
 Spleen Antibodies  >1 publications with FCRL5 and Spleen
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