PAK1 Antibody – Rabbit Polyclonal

PAK1: a protein kinase of the STE20 family that regulates cell motility and morphology. Critical RhoGTPase effector that regulates cytoskeleton reorganization, the JNK MAPK pathway, and nuclear signaling. Binding of Rac/cdc42 to the PBD of PAK1 causes autophosphorylation and conformational change. Phosphorylated and activated by PDK.

Protein type: EC 2.7.11.1; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; STE group; STE20 family; PAKA subfamily

Chromosomal Location of Human Ortholog: 11q13-q14

Cellular Component: Golgi apparatus; nuclear membrane; focal adhesion; protein complex; dendrite; intercellular junction; cytosol; Z disc; filamentous actin; ruffle; growth cone; axon; cytoplasm; plasma membrane

Molecular Function: collagen binding; protein serine/threonine kinase activity; protein binding; protein kinase binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity

Biological Process: axon guidance; positive regulation of JNK activity; exocytosis; wound healing; apoptosis; protein amino acid autophosphorylation; positive regulation of estrogen receptor signaling pathway; MAPKKK cascade; protein amino acid phosphorylation; receptor clustering; positive regulation of peptidyl-serine phosphorylation; T cell receptor signaling pathway; cellular response to insulin stimulus; branching morphogenesis of a tube; T cell costimulation; positive regulation of stress fiber formation; actin cytoskeleton reorganization; response to hypoxia; ephrin receptor signaling pathway; dendrite development; innate immune response; mitotic cell cycle; positive regulation of protein amino acid phosphorylation; vascular endothelial growth factor receptor signaling pathway; neuromuscular junction development; neurite morphogenesis