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EIF2C3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS417603

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
EIF2C3, Polyclonal Antibody
Full Product Name
Anti-EIF2C3 Antibody
Product Gene Name
anti-EIF2C3 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human. Predicted: Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
71,211 Da
OMIM
607355
Storage Buffer
PBS, pH 7.4 with 0.02% sodium azide.
Immunogen
Rabbit polyclonal EIF2C3(1) antibody was raised against a peptide from the intermediate residues of human EIF2C3 protein.
Applications Tested/Suitable for anti-EIF2C3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-EIF2C3 antibody
ELISA titer: 1:20,000-1:80,000
Western blot analysis: 1:500-1:1,000
Immunohistochemistry: 1:100-1:500
Optimal dilutions/concentrations should be determined by the end user

Testing Data of anti-EIF2C3 antibody

Rabbit Anti-EIF2C3 Polyclonal Antibody – Cat# MBS417603

Testing Data of anti-EIF2C3 antibody

Rabbit Anti-EIF2C3 Polyclonal Antibody, Testing Data – Cat# MBS417603

Product References and Citations for anti-EIF2C3 antibody

(1) Hu,Q., Tanasa,B., Trabucchi,M., et al. DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation. Nat. Struct. Mol. Biol. 19 (11), 1168-1175 (2012)

Other Notes

Small volumes of anti-EIF2C3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EIF2C3 purchase

MBS417603 is an antibody targeting EIF2C3. Reactive in Human. Predicted: Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EIF2C3. It may not necessarily be applicable to this product.

NCBI GI #
44890571
NCBI GeneID
192669
NCBI Accession #
AAH66888.1
UniProt Secondary Accession #
Q5TA55; Q9H1U6; B1ALI0
UniProt Related Accession #
Q9H9G7
NCBI Official Full Name
EIF2C3 protein
NCBI Official Synonym Full Names
argonaute RISC catalytic component 3
NCBI Official Symbol
AGO3
NCBI Official Synonym Symbols
EIF2C3
UniProt Protein Name
Protein argonaute-3
UniProt Synonym Protein Names
Argonaute RISC catalytic component 3; Eukaryotic translation initiation factor 2C 3
UniProt Gene Name
AGO3
UniProt Entry Name
AGO3_HUMAN
NCBI Protein Information
protein argonaute-3; argonaute 3; eukaryotic translation initiation factor 2C, 3; hAgo3

UniProt Comments for EIF2C3

AGO3: Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Belongs to the argonaute family. Ago subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation; Translation initiation

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: membrane; cytoplasm; cytosol

Molecular Function: protein binding; miRNA binding

Biological Process: epidermal growth factor receptor signaling pathway; Notch signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; miRNA-mediated gene silencing, mRNA cleavage; mRNA catabolic process; innate immune response; miRNA-mediated gene silencing, negative regulation of translation; gene expression; posttranscriptional gene silencing
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Research Articles on EIF2C3

1. Study uncovers a first example of a vertebrate protein factor, Argonaute-3, specifically affecting the guide-to-passenger-strand ratio of the miRNA let-7a. A multi-layered mechanism for the observed impact of Ago3 on the let-7a-3p passenger strand expression and activity is proposed.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EIF2C3 antibody

 Reference Product  PubMed Publications
 EIF2C2 antibody  >9 publications with EIF2C3 and EIF2C2
 EIF2C1 antibody  >6 publications with EIF2C3 and EIF2C1
 EIF2C4 antibody  >4 publications with EIF2C3 and EIF2C4
 DICER1 antibody  >3 publications with EIF2C3 and DICER1
 TARBP2 antibody  >1 publications with EIF2C3 and TARBP2

Pathways associated with anti-EIF2C3 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Ca2+ Pathway antibodies  Ca2+ Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram

Diseases associated with anti-EIF2C3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with EIF2C3 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >1 publications with EIF2C3 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with EIF2C3 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with EIF2C3 and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with EIF2C3 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-EIF2C3 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >10 publications with EIF2C3 and Testis
 Brain Antibodies  >3 publications with EIF2C3 and Brain
 Liver Antibodies  >2 publications with EIF2C3 and Liver
 Muscle Antibodies  >1 publications with EIF2C3 and Muscle
 Heart Antibodies  >1 publications with EIF2C3 and Heart
 Lung Antibodies  >1 publications with EIF2C3 and Lung
 Blood Antibodies  >1 publications with EIF2C3 and Blood
 Kidney Antibodies  >1 publications with EIF2C3 and Kidney
 Skin Antibodies  >1 publications with EIF2C3 and Skin
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