• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

GATA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS417616

This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
GATA1, Polyclonal Antibody
Full Product Name
Anti-GATA1 Antibody
Product Gene Name
anti-GATA1 antibody
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1ug/ul (lot specific)
Specificity
GATA1 (Ab-310) antibody detects endogenous levels of total GATA1 protein.
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
34,232 Da
OMIM
300367
Storage Buffer
phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized non-phosphopeptide derived from human GATA1 around the phosphorylation site of serine 310 (K-A-SP-G-K).
Applications Tested/Suitable for anti-GATA1 antibody
Western Blot (WB)
Application Notes for anti-GATA1 antibody
WB: 1:500~1:1000

Product References and Citations for anti-GATA1 antibody

Kadri Z, et al.(2005)Mol Cell Biol 2005 Sep; 25(17): 7412-22.

Other Notes

Small volumes of anti-GATA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GATA1 purchase

MBS417616 is an antibody targeting GATA1. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GATA1. It may not necessarily be applicable to this product.

NCBI GI #
14602571
NCBI GeneID
2623
NCBI Accession #
AAH09797.1
UniProt Secondary Accession #
Q96GB8
UniProt Related Accession #
P15976
NCBI Official Full Name
GATA1 protein
NCBI Official Synonym Full Names
GATA binding protein 1 (globin transcription factor 1)
NCBI Official Symbol
GATA1
NCBI Official Synonym Symbols
GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1
UniProt Protein Name
Erythroid transcription factor
UniProt Synonym Protein Names
Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein
Protein Family
Erythroid transcription factor
UniProt Gene Name
GATA1
UniProt Entry Name
GATA1_HUMAN
NCBI Protein Information
erythroid transcription factor; GATA-binding factor 1; NF-E1 DNA-binding protein; erythroid transcription factor 1; globin transcription factor 1; nuclear factor, erythroid 1; transcription factor GATA1

UniProt Comments for GATA1

GATA1: Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. May form homodimers or heterodimers with other isoforms. Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner. Interacts with LMCD1. Interacts with CREBBP; the interaction stimulates acetylation and transcriptional activity in vivo. Interacts with EP300. Erythrocytes. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: nucleoplasm; transcription factor complex; transcriptional repressor complex; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; chromatin DNA binding; p53 binding; DNA bending activity; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; erythrocyte development; in utero embryonic development; megakaryocyte differentiation; embryonic hemopoiesis; positive regulation of erythrocyte differentiation; male gonad development; eosinophil differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; negative regulation of bone mineralization; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell signaling; positive regulation of osteoblast proliferation; erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; platelet formation; blood coagulation; basophil differentiation; negative regulation of apoptosis

Disease: Thrombocytopenia With Beta-thalassemia, X-linked; Anemia, X-linked, With Or Without Neutropenia And/or Platelet Abnormalities; Down Syndrome; Thrombocytopenia, X-linked, With Or Without Dyserythropoietic Anemia
Show more

Research Articles on GATA1

1. Data indicate that GATA1 transcription factor is downregulated in ribosomal protein S19 (RPS19)-deficient cells through upregulation of TNF-alpha and p38 MAPK.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GATA1 antibody

 Reference Product  PubMed Publications
 TAL1 antibody  >111 publications with GATA1 and TAL1
 ZFPM1 antibody  >68 publications with GATA1 and ZFPM1
 MYB antibody  >41 publications with GATA1 and MYB
 ZFPM2 antibody  >7 publications with GATA1 and ZFPM2
 CREBBP antibody  >6 publications with GATA1 and CREBBP
 HEY1 antibody  >5 publications with GATA1 and HEY1
 HDAC1 antibody  >5 publications with GATA1 and HDAC1
 HDAC5 antibody  >4 publications with GATA1 and HDAC5
 HDAC3 antibody  >3 publications with GATA1 and HDAC3
 HDAC4 antibody  >2 publications with GATA1 and HDAC4

Pathways associated with anti-GATA1 antibody

 Products by Pathway  Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram
 Signaling Events Mediated By HDAC Class II Pathway antibodies  Signaling Events Mediated By HDAC Class II Pathway Diagram

Diseases associated with anti-GATA1 antibody

 Disease Name  Pubmed Publications
 THROMBOCYTOPENIA, X-LINKED, WITH OR WITHOUT DYSERYTHROPOIETIC ANEMIA Antibodies  >683 publications with GATA1 and THROMBOCYTOPENIA, X-LINKED, WITH OR WITHOUT DYSERYTHROPOIETIC ANEMIA
 Leukemia Antibodies  >407 publications with GATA1 and Leukemia
 Leukemia, Myeloid, Acute Antibodies  >253 publications with GATA1 and Leukemia, Myeloid, Acute
 Bone Marrow Diseases Antibodies  >231 publications with GATA1 and Bone Marrow Diseases
 Down Syndrome Antibodies  >184 publications with GATA1 and Down Syndrome
 Anemia Antibodies  >155 publications with GATA1 and Anemia
 Thrombocytopenia Antibodies  >68 publications with GATA1 and Thrombocytopenia
 Chromosome Aberrations Antibodies  >46 publications with GATA1 and Chromosome Aberrations
 Cell Transformation, Neoplastic Antibodies  >31 publications with GATA1 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >28 publications with GATA1 and Inflammation

Organs/Tissues associated with anti-GATA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >203 publications with GATA1 and Bone Marrow
 Lung Antibodies  >21 publications with GATA1 and Lung
 Muscle Antibodies  >14 publications with GATA1 and Muscle
 Connective Tissue Antibodies  >8 publications with GATA1 and Connective Tissue
 Uncharacterized Tissue Antibodies  >1 publications with GATA1 and Uncharacterized Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000