CORONIN 1a Antibody – Polyclonal

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

coronin 1A: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. Belongs to the WD repeat coronin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: actin filament; axon; cortical actin cytoskeleton; cytoplasm; cytosol; early endosome; immunological synapse; intercellular junction; lamellipodium; membrane; nucleus; phagocytic cup; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; protein complex

Molecular Function: actin binding; actin filament binding; actin monomer binding; cytoskeletal protein binding; myosin heavy chain binding; phosphoinositide 3-kinase binding; protein binding; protein C-terminus binding; protein homodimerization activity

Biological Process: actin cytoskeleton organization and biogenesis; actin filament organization; calcium ion transport; cell motility; cell-substrate adhesion; formation of immunological synapse; homeostasis of number of cells within a tissue; innate immune response; leukocyte chemotaxis; natural killer cell degranulation; negative regulation of actin nucleation; negative regulation of neuron apoptosis; negative regulation of vesicle fusion; phagocytosis; phagolysosome formation; positive chemotaxis; positive regulation of cell migration; positive regulation of T cell proliferation; regulation of actin cytoskeleton organization and biogenesis; regulation of cell shape; regulation of release of sequestered calcium ion into cytosol; T cell homeostasis; uropod organization and biogenesis

Disease: Immunodeficiency 8