Collagen XIV Alpha1 (COL14A1) Antibody – Rabbit

COL14A1: Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors. Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Extracellular matrix; Secreted

Chromosomal Location of Human Ortholog: 8q23

Cellular Component: collagen type XIV; extracellular matrix; proteinaceous extracellular matrix; extracellular space; collagen; endoplasmic reticulum lumen; extracellular region

Molecular Function: collagen binding; protein binding, bridging; extracellular matrix structural constituent

Biological Process: collagen catabolic process; extracellular matrix disassembly; cell-cell adhesion; extracellular matrix organization and biogenesis; collagen fibril organization; homeostasis of number of cells within a tissue