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AQP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS418052

MBS418052 is an antibody targeting AQP2. Also known as Anti-AQP2 (aquaporin 2)- (N-terminal) Antibody. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
AQP2 (aquaporin 2), Polyclonal Antibody
Full Product Name
Anti-AQP2 (aquaporin 2)- (N-terminal) Antibody
Product Gene Name
anti-AQP2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Purified by antigen-specific affinity chromatography.
Concentration
1ug/ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
28,837 Da
OMIM
Z29491 Genomic DNA
Immunogen
Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human AQP2 (aquaporin 2)
Storage Buffer
PBS, pH 7.4 with 0.05% sodium azide.
Applications Tested/Suitable for anti-AQP2 antibody
Western Blot (WB), ELISA (EIA)

Product References and Citations for anti-AQP2 antibody

Hirano, K., et al, Am. J. Pathol. 163 (1), 111-120 (2003) gura, T., et al, Horm. Res. 59 (1), 30-34 (2003) van Balkom, B.W., et al, J. Biol. Chem. 277 (44), 41473-41479 (2002) Marr, N., et al, J. Am. Soc. Nephrol. 13 (9), 2267-2277 (2002) Lin, S.H., et al, J. Clin. Endocrinol. Metab. 87 (6), 2694-2700 (2002) Kusaka, I., et al, Nephron 91 (1), 167-169 (2002) Marr, N., et al, Hum. Mol. Genet. 11 (7), 779-789 (2002)

Other Notes

Small volumes of anti-AQP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AQP2. It may not necessarily be applicable to this product.

NCBI GI #
5052748
NCBI GeneID
359
NCBI Accession #
AAD38692.1
UniProt Secondary Accession #
Q9UD68
UniProt Related Accession #
P41181
NCBI Official Full Name
aquaporin 2
NCBI Official Synonym Full Names
aquaporin 2
NCBI Official Symbol
AQP2
NCBI Official Synonym Symbols
AQP-CD; WCH-CD
UniProt Protein Name
Aquaporin-2
UniProt Synonym Protein Names
ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct
UniProt Gene Name
AQP2
UniProt Synonym Gene Names
AQP-2; AQP-CD
NCBI Protein Information
aquaporin-2

NCBI Summary for AQP2

This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus. [provided by RefSeq, Oct 2008]
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UniProt Comments for AQP2

AQP2: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Expressed in renal collecting tubules. Belongs to the MIP/aquaporin (TC 1.A.8) family.

Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family

Chromosomal Location of Human Ortholog: 12q13.12

Cellular Component: apical plasma membrane; integral to plasma membrane; membrane; plasma membrane

Molecular Function: glycerol channel activity; glycerol transmembrane transporter activity; water channel activity; water transporter activity

Biological Process: cellular water homeostasis; excretion; glycerol transport; renal water homeostasis; water transport

Disease: Diabetes Insipidus, Nephrogenic, Autosomal
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Research Articles on AQP2

1. AQP2 polymorphisms (rs461872, rs7305534) were correlated with gastrointestinal toxicity of platinum-based chemotherapy in lung cancer patients

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AQP2 antibody

 Reference Product  PubMed Publications
 AQP3 antibody  >220 publications with AQP2 and AQP3
 AVP antibody  >218 publications with AQP2 and AVP
 AQP4 antibody  >139 publications with AQP2 and AQP4
 SLC12A1 antibody  >41 publications with AQP2 and SLC12A1
 MYO5B antibody  >1 publications with AQP2 and MYO5B

Pathways associated with anti-AQP2 antibody

 Products by Pathway  Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Passive Transport By Aquaporins Pathway antibodies  Passive Transport By Aquaporins Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway antibodies  Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram

Diseases associated with anti-AQP2 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >335 publications with AQP2 and Kidney Diseases
 Diabetes Insipidus, Nephrogenic Antibodies  >248 publications with AQP2 and Diabetes Insipidus, Nephrogenic
 Polyuria Antibodies  >137 publications with AQP2 and Polyuria
 Disease Models, Animal Antibodies  >94 publications with AQP2 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >72 publications with AQP2 and Cardiovascular Diseases
 Heart Failure Antibodies  >55 publications with AQP2 and Heart Failure
 Hypertension Antibodies  >52 publications with AQP2 and Hypertension
 Heart Diseases Antibodies  >48 publications with AQP2 and Heart Diseases
 Brain Diseases Antibodies  >38 publications with AQP2 and Brain Diseases
 Renal Insufficiency Antibodies  >33 publications with AQP2 and Renal Insufficiency

Organs/Tissues associated with anti-AQP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >890 publications with AQP2 and Kidney
 Brain Antibodies  >76 publications with AQP2 and Brain
 Eye Antibodies  >26 publications with AQP2 and Eye
 Testis Antibodies  >9 publications with AQP2 and Testis
 Prostate Antibodies  >4 publications with AQP2 and Prostate
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