CTDP1 Antibody – Rabbit Polyclonal

This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

CTDP1: a phospho-serine/threonine protein phosphatase which interacts with the carboxy-terminus of transcription initiation factor TFIIF-alpha, a transcription factor which regulates elongation as well as initiation by RNA polymerase II. Its phosphorylation increases binding to TFIIF-alpha, affecting transcription elongation. Alternative splicing results in two different isoforms.

Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex

Chromosomal Location of Human Ortholog: 18q23

Cellular Component: actin cytoskeleton; centrosome; DNA-directed RNA polymerase II, holoenzyme; midbody; nucleoplasm; spindle; spindle midzone; spindle pole

Molecular Function: CTD phosphatase activity; phosphoprotein phosphatase activity; protein binding

Biological Process: exit from mitosis; positive regulation of viral transcription; protein amino acid dephosphorylation; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter

Disease: Congenital Cataracts, Facial Dysmorphism, And Neuropathy