Rabbit Anti-DERL2 Polyclonal Antibody – Cat# MBS418097

DERL2 Antibody – Rabbit Polyclonal

Name: DERL2 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS418097
Price: 685 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS418097

DERL2 (Derlin-2) may be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. Its precise role is however unclear. In contrast to DER1, it is not involved in the degradation of MHC class I heavy chains in cas… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

DERL2 (Derlin-2), Polyclonal Antibody

Full Product Name

Anti-DERL2 (Derlin-2) Antibody

Product Gene Name

anti-DERL2 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Liquid

Purity/Purification

Purified by antigen-specific affinity chromatography.

Concentration

1ug/ul (lot specific)

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

27,815 Da

3D Structure

ModBase 3D Structure for Q8BNI4

Immunogen

Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DERL2 (Derlin-2)

Storage Buffer

PBS, pH 7.4 with 0.05% sodium azide.

Applications Tested/Suitable for anti-DERL2 antibody

Western Blot (WB), ELISA (EIA)

Product References and Citations for anti-DERL2 antibody

Ying, H., et al, Biochem. Biophys. Res. Commun. 286 (2), 394-400 (2001) Lai, C.H., et al, Genome Res. 10 (5), 703-713 (2000) Lilley, B.N. and Ploegh, H.L., Nature 429 (6994), 834-840 (2004)

Other Notes

Small volumes of anti-DERL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DERL2 purchase

MBS418097 is an antibody targeting DERL2. Also known as Anti-DERL2 (Derlin-2) Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DERL2. It may not necessarily be applicable to this product.

NCBI GI #

599045397

NCBI GeneID

116891

NCBI Accession #

NP_001278076.1

UniProt Primary Accession #

Q8BNI4

UniProt Secondary Accession #

Q920I5; Q99J12

UniProt Related Accession #

Q8BNI4

GenBank Nucleotide #

NM_001291147.1

NCBI Official Full Name

derlin-2 isoform b

NCBI Official Synonym Full Names

Der1-like domain family, member 2

NCBI Official Symbol

Derl2

NCBI Official Synonym Symbols

Flana; F-lana; CGI-101; Derlin-2

UniProt Protein Name

Derlin-2

UniProt Synonym Protein Names

Degradation in endoplasmic reticulum protein 2; Der1-like protein 2; F-LANa

Protein Family

Derlin

UniProt Gene Name

Derl2

UniProt Synonym Gene Names

Der2; Flana

NCBI Protein Information

derlin-2

UniProt Comments for DERL2

DERL2: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation. Belongs to the derlin family.

Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11 B4|11 43.21 cM

Cellular Component: early endosome; endoplasmic reticulum; integral to endoplasmic reticulum membrane; late endosome; membrane

Biological Process: ER-associated protein catabolic process; positive regulation of cell growth; positive regulation of cell proliferation; retrograde protein transport, ER to cytosol; suckling behavior; unfolded protein response

Research Articles on DERL2

1. Whole-body deletion of derlin-2 leads to perinatal lethality and skeletal abnormalities.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DERL2 antibody

Reference Product	PubMed Publications
Syvn1 antibody	>5 publications with DERL2 and Syvn1
Edem1 antibody	>3 publications with DERL2 and Edem1
Sel1l antibody	>3 publications with DERL2 and Sel1l

Pathways associated with anti-DERL2 antibody

Products by Pathway	Pathway Diagram
Asparagine N-linked Glycosylation Pathway antibodies	Asparagine N-linked Glycosylation Pathway Diagram
Calnexin/calreticulin Cycle Pathway antibodies	Calnexin/calreticulin Cycle Pathway Diagram
ER Quality Control Compartment (ERQC) Pathway antibodies	ER Quality Control Compartment (ERQC) Pathway Diagram
HRD1/SEL1 ERAD Complex Pathway antibodies	HRD1/SEL1 ERAD Complex Pathway Diagram
HRD1/SEL1 ERAD Complex Pathway antibodies	HRD1/SEL1 ERAD Complex Pathway Diagram
Hedgehog Ligand Biogenesis Pathway antibodies	Hedgehog Ligand Biogenesis Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
N-glycan Trimming In The ER And Calnexin/Calreticulin Cycle Pathway antibodies	N-glycan Trimming In The ER And Calnexin/Calreticulin Cycle Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with anti-DERL2 antibody

Disease Name	Pubmed Publications
Liver Neoplasms Antibodies	>2 publications with DERL2 and Liver Neoplasms
Liver Diseases Antibodies	>2 publications with DERL2 and Liver Diseases
Disease Models, Animal Antibodies	>1 publications with DERL2 and Disease Models, Animal
Fetal Death Antibodies	>1 publications with DERL2 and Fetal Death
Neoplasms, Experimental Antibodies	>1 publications with DERL2 and Neoplasms, Experimental
Cell Transformation, Neoplastic Antibodies	>1 publications with DERL2 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-DERL2 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>4 publications with DERL2 and Liver
Brain Antibodies	>2 publications with DERL2 and Brain
Kidney Antibodies	>1 publications with DERL2 and Kidney
Pancreas Antibodies	>1 publications with DERL2 and Pancreas
Embryonic Tissue Antibodies	>1 publications with DERL2 and Embryonic Tissue