Rabbit Anti-DSG4 Polyclonal Antibody – Cat# MBS418107

DSG4 Antibody – Rabbit Polyclonal

Name: DSG4 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS418107
Price: 685 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS418107

DSG4 (Desmoglein-4) is a component of intercellular desmosome junctions. DSG4 is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSG4 coordinates the transition from proliferation to differentiation in… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

DSG4 (Desmoglein-4), Polyclonal Antibody

Full Product Name

Anti-DSG4 (Desmoglein-4)- (C-terminal) Antibody

Product Gene Name

anti-DSG4 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Liquid

Purity/Purification

Purified by antigen-specific affinity chromatography.

Concentration

0.5mg/ml (lot specific)

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

115,451 Da

OMIM

AY227350 mRNA

3D Structure

ModBase 3D Structure for Q86SJ6

Immunogen

Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human DSG4 (Desmoglein-4 precursor)

Storage Buffer

PBS, pH 7.4 with 0.05% sodium azide and 50% glycerol

Applications Tested/Suitable for anti-DSG4 antibody

Western Blot (WB), ELISA (EIA)

Product References and Citations for anti-DSG4 antibody

Kljuic, A., et al, Cell 113 (2), 249-260 (2003)Whittock, N.V. and Bower, C., J. Invest. Dermatol. 120 (4),523-530 (2003)Bazzi, H., et al, Differentiation 74 (2-3), 129-140 (2006)Bazzi, H., et al, J. Investig. Dermatol. Symp. Proc. 10 (3), 222-224 (2005)Nagasaka, T., et al, J. Clin. Invest. 114 (10), 1484-1492 (2004)Kljuic, A., et al, Cell 113 (2), 249-260 (2003)Whittock, N.V. et al, J. Invest. Dermatol. 120 (4),523-530 (2003)

Other Notes

Small volumes of anti-DSG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DSG4 purchase

MBS418107 is an antibody targeting DSG4. Also known as Anti-DSG4 (Desmoglein-4)- (C-terminal) Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DSG4. It may not necessarily be applicable to this product.

NCBI GI #

29789445

NCBI GeneID

147409

NCBI Accession #

NP_817123.1

UniProt Primary Accession #

Q86SJ6

UniProt Secondary Accession #

Q6Y9L9; Q8IXV4; A2RUI1

UniProt Related Accession #

Q86SJ6

GenBank Nucleotide #

NM_177986.4

NCBI Official Full Name

desmoglein-4 isoform 2 preproprotein

NCBI Official Synonym Full Names

desmoglein 4

NCBI Official Symbol

DSG4

NCBI Official Synonym Symbols

LAH; HYPT6; CDGF13; CDHF13

UniProt Protein Name

Desmoglein-4

UniProt Synonym Protein Names

Cadherin family member 13

Protein Family

Desmoglein

UniProt Gene Name

DSG4

UniProt Synonym Gene Names

CDHF13

NCBI Protein Information

desmoglein-4

NCBI Summary for DSG4

This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a transmembrane component of desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and monilethrix, characterized by impaired hair growth. [provided by RefSeq, May 2016]

UniProt Comments for DSG4

DSG4: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. Defects in DSG4 are the cause of hypotrichosis type 6 (HYPT6). A condition characterized by the presence of less than the normal amount of hair, involving mainly the scalp, chest, arms and legs. It is characterized by abnormal hair follicles and shafts, which are thin and atrophic. Autoantibodies against DSG4 are found in patients with pemphigus vulgaris. Pemphigus vulgaris is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q12.1

Disease: Hypotrichosis 6

Research Articles on DSG4

1. This study further extends the body of evidence that mutations in the DSG4 gene result in both hypotrichosis and monilethrix-like scalp hair.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DSG4 antibody

Reference Product	PubMed Publications
KRT83 antibody	>2 publications with DSG4 and KRT83
LPAR6 antibody	>2 publications with DSG4 and LPAR6

Diseases associated with anti-DSG4 antibody

Disease Name	Pubmed Publications
Hypotrichosis Antibodies	>25 publications with DSG4 and Hypotrichosis
Autoimmune Diseases Antibodies	>12 publications with DSG4 and Autoimmune Diseases
Cardiomyopathies Antibodies	>1 publications with DSG4 and Cardiomyopathies

Organs/Tissues associated with anti-DSG4 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>1 publications with DSG4 and Testis
Prostate Antibodies	>1 publications with DSG4 and Prostate