Rabbit Anti-KCNE1 Polyclonal Antibody – Cat# MBS418146

KCNE1 Antibody – Rabbit Polyclonal

Name: KCNE1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS418146
Price: 685 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS418146

KCNE1 (Potassium voltage-gated channel subfamily E member 1) is an ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. KCNE1 modulates the gating kinetics and enhances stability of… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

KCNE1, Polyclonal Antibody

Full Product Name

Anti-KCNE1 (Potassium voltage-gated channel subfamily E member 1) Antibody

Product Gene Name

anti-KCNE1 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid

Purity/Purification

Purified by antigen-specific affinity chromatography.

Concentration

1ug/ul (lot specific)

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

14,675 Da

OMIM

M26685 Genomic DNA

Immunogen

Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human KCNE1 (Potassium voltage-gated channel subfamily E member 1)

Storage Buffer

PBS, pH 7.4 with 0.05% sodium azide.

Applications Tested/Suitable for anti-KCNE1 antibody

Western Blot (WB), ELISA (EIA)

Product References and Citations for anti-KCNE1 antibody

Murai, T., et al, Biochem. Biophys. Res. Commun. 161 (1), 176-181 (1989)Chouabe, C., et al, EMBO J. 16 (17),5472-5479 (1997)McDonald, T.V., et al, Nature 388 (6639), 289-292 (1997)Abbott, G.W. and Goldstein, S.A., FASEB J. 16 (3), 390-400 (2002)Tesson, F., et al, J. Mol. Cell. Cardiol. 28 (9), 2051-2055 (1996)Tyson, J., et al, Hum. Mol. Genet. 6 (12), 2179-2185 (1997)Schulze-Bahr, E., et al, Nat. Genet. 17 (3), 267-268 (1997)Splawski, I., et al, Nat. Genet. 17 (3), 338-340 (1997)Duggal, P., et al, Circulation 97 (2), 142-146 (1998)Splawski, I., et al, Circulation 102 (10), 1178-1185 (2000)Schulze-Bahr, E., et al, J. Mol. Med. 79 (9),504-509 (2001)

Other Notes

Small volumes of anti-KCNE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNE1 purchase

MBS418146 is an antibody targeting KCNE1. Also known as Anti-KCNE1 (Potassium voltage-gated channel subfamily E member 1) Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNE1. It may not necessarily be applicable to this product.

NCBI GI #

49456471

NCBI GeneID

3753

NCBI Accession #

CAG46556.1

UniProt Secondary Accession #

Q8N709; Q91Z94; A5H1P2

UniProt Related Accession #

P15382

NCBI Official Full Name

KCNE1, partial

NCBI Official Synonym Full Names

potassium voltage-gated channel subfamily E regulatory subunit 1

NCBI Official Symbol

KCNE1

NCBI Official Synonym Symbols

ISK; JLNS; LQT5; MinK; JLNS2; LQT2/5

UniProt Protein Name

Potassium voltage-gated channel subfamily E member 1

UniProt Synonym Protein Names

Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Minimal potassium channel

Protein Family

Potassium voltage-gated channel subfamily

UniProt Gene Name

KCNE1

NCBI Protein Information

potassium voltage-gated channel subfamily E member 1

NCBI Summary for KCNE1

The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

UniProt Comments for KCNE1

KCNE1: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Associates with KCNQ1/KVLQT1 and KCNH2/HERG. Expressed in heart, lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells. Belongs to the potassium channel KCNE family.

Protein type: Channel, potassium; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.12

Cellular Component: apical plasma membrane; cell surface; lysosome; plasma membrane; voltage-gated potassium channel complex; Z disc

Molecular Function: delayed rectifier potassium channel activity; potassium channel regulator activity; protein binding; telethonin binding; voltage-gated potassium channel activity

Biological Process: protein amino acid N-linked glycosylation; protein amino acid O-linked glycosylation; sensory perception of sound

Disease: Jervell And Lange-nielsen Syndrome 2; Long Qt Syndrome 5

Research Articles on KCNE1

1. A stoichiometry of 4:4 between the alpha KCNE1 and the beta KCNQ1-subunits has been established.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNE1 antibody

Reference Product	PubMed Publications
FLNA antibody	>12 publications with KCNE1 and FLNA

Pathways associated with anti-KCNE1 antibody

Products by Pathway	Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram
Salmonella Infection Pathway antibodies	Salmonella Infection Pathway Diagram

Diseases associated with anti-KCNE1 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>233 publications with KCNE1 and Cardiovascular Diseases
Heart Diseases Antibodies	>228 publications with KCNE1 and Heart Diseases
Long QT Syndrome Antibodies	>198 publications with KCNE1 and Long QT Syndrome
Jervell-Lange Nielsen Syndrome Antibodies	>39 publications with KCNE1 and Jervell-Lange Nielsen Syndrome
Nervous System Diseases Antibodies	>30 publications with KCNE1 and Nervous System Diseases
Torsades de Pointes Antibodies	>23 publications with KCNE1 and Torsades de Pointes
Hypertension Antibodies	>13 publications with KCNE1 and Hypertension
Heart Failure Antibodies	>10 publications with KCNE1 and Heart Failure
Bradycardia Antibodies	>10 publications with KCNE1 and Bradycardia
Seizures Antibodies	>9 publications with KCNE1 and Seizures

Organs/Tissues associated with anti-KCNE1 antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>33 publications with KCNE1 and Kidney
Blood Antibodies	>27 publications with KCNE1 and Blood
Brain Antibodies	>21 publications with KCNE1 and Brain
Intestine Antibodies	>16 publications with KCNE1 and Intestine
Lung Antibodies	>8 publications with KCNE1 and Lung
Nerve Antibodies	>6 publications with KCNE1 and Nerve
Testis Antibodies	>4 publications with KCNE1 and Testis
Trachea Antibodies	>1 publications with KCNE1 and Trachea