PAK1 Antibody – Rabbit Polyclonal

This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

PAK1: a protein kinase of the STE20 family that regulates cell motility and morphology. Critical RhoGTPase effector that regulates cytoskeleton reorganization, the JNK MAPK pathway, and nuclear signaling. Binding of Rac/cdc42 to the PBD of PAK1 causes autophosphorylation and conformational change. Phosphorylated and activated by PDK.

Protein type: EC 2.7.11.1; Kinase, protein; PAKA subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family

Chromosomal Location of Human Ortholog: 11q13.5-q14.1

Cellular Component: axon; cytoplasm; cytosol; dendrite; Golgi apparatus; intercellular junction; nuclear membrane; plasma membrane; protein complex; ruffle; Z disc

Molecular Function: collagen binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: actin cytoskeleton reorganization; axonogenesis; branching morphogenesis of a tube; ephrin receptor signaling pathway; MAPKKK cascade; mitotic cell cycle; neurite morphogenesis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of estrogen receptor signaling pathway; positive regulation of JNK activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of stress fiber formation; protein amino acid autophosphorylation; protein amino acid phosphorylation; stimulatory C-type lectin receptor signaling pathway; T cell costimulation; T cell receptor signaling pathway; wound healing