RAMP2 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]

RAMP2: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. Belongs to the RAMP family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cell surface; coated pit; cytoplasm; integral to plasma membrane; lysosome; plasma membrane; receptor complex

Molecular Function: coreceptor activity; protein binding; protein transporter activity

Biological Process: angiogenesis; calcium ion transport; cAMP biosynthetic process; heart development; negative regulation of vascular permeability; positive regulation of angiogenesis; positive regulation of cAMP biosynthetic process; protein transport; receptor internalization; regulation of blood pressure; sprouting angiogenesis; vasculogenesis