RYR3 Antibody – Rabbit Polyclonal

The protein encoded by this gene is a ryanodine receptor, which functions to release calcium from intracellular storage for use in many cellular processes. For example, the encoded protein is involved in skeletal muscle contraction by releasing calcium from the sarcoplasmic reticulum followed by depolarization of T-tubules. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

RYR3: Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis. Plays a role in cellular calcium signaling. Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR3 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 15q13.3-q14

Cellular Component: integral to membrane; sarcolemma; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; Z disc

Molecular Function: calcium ion binding; calcium-induced calcium release activity; calcium-release channel activity; ryanodine-sensitive calcium-release channel activity

Biological Process: calcium ion transport; protein homotetramerization