Rabbit Anti-SytVI Polyclonal Antibody – Cat# MBS418256

SytVI Antibody – Rabbit Polyclonal

Name: SytVI Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS418256
Price: 685 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS418256

The SytVI (Synaptotagmin VI) may be involved in Ca (2+)-dependent exocytosis of secretory vesicles through Ca (2+) and phospholipid binding to the C2 domain or may serve as Ca (2+) sensors in the process of vesicular trafficking and exocytosis.It belongs to… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

SytVI (Synaptotagmin VI), Polyclonal Antibody

Full Product Name

Anti-SytVI (Synaptotagmin VI) Antibody

Product Gene Name

anti-SytVI antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Liquid

Purity/Purification

Purified by antigen-specific affinity chromatography.

Concentration

1ug/ul (lot specific)

Preparation and Storage

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Molecular Weight

48,442 Da

OMIM

AK056448 mRNA

3D Structure

ModBase 3D Structure for Q5T7P8

Immunogen

Polyclonal antibody produced in rabbits immunizing with a synthetic phospho-peptide corresponding to C-terminal residues of human SytVI (Synaptotagmin VI)

Storage Buffer

PBS, pH 7.4 with 0.05% sodium azide.

Applications Tested/Suitable for anti-SytVI antibody

Western Blot (WB), ELISA (EIA)

Product References and Citations for anti-SytVI antibody

Fukuda, M., et al, J. Biol. Chem. 274 (44), 31421-31427 (1999)

Other Notes

Small volumes of anti-SytVI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SytVI purchase

MBS418256 is an antibody targeting SytVI. Also known as Anti-SytVI (Synaptotagmin VI) Antibody. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SytVI. It may not necessarily be applicable to this product.

NCBI GI #

399154127

NCBI GeneID

148281

NCBI Accession #

NP_001257734.1

UniProt Primary Accession #

Q5T7P8

UniProt Secondary Accession #

B1AMB8; B3KPK1

UniProt Related Accession #

Q5T7P8

GenBank Nucleotide #

NM_001270805.1

NCBI Official Full Name

synaptotagmin-6

NCBI Official Synonym Full Names

synaptotagmin 6

NCBI Official Symbol

SYT6

NCBI Official Synonym Symbols

sytVI

UniProt Protein Name

Synaptotagmin-6

UniProt Synonym Protein Names

Synaptotagmin VI; SytVI

UniProt Gene Name

SYT6

UniProt Synonym Gene Names

SytVI

NCBI Protein Information

synaptotagmin-6

NCBI Summary for SytVI

The protein encoded by this gene belongs to the synaptotagmin family. Synaptotagmins share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains, and are involved in calcium-dependent exocytosis of synaptic vesicles. This protein has been shown to be a key component of the secretory machinery involved in acrosomal exocytosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]

UniProt Comments for SytVI

SYT6: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)- regulation of exocytosis in acrosomal reaction in sperm. Belongs to the synaptotagmin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: cytosol; extrinsic to membrane; integral to membrane; plasma membrane

Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; protein homodimerization activity; syntaxin binding

Biological Process: calcium ion-dependent exocytosis of neurotransmitter; regulation of calcium ion-dependent exocytosis; vesicle fusion

Research Articles on SytVI

1. synaptotagmin must be dephosphorylated at a specific window of time and phosphorylated synaptotagmin has an active role at early stages of the acrosomal exocytosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SytVI antibody

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>1 publications with SytVI and Heart Diseases
Adenocarcinoma Antibodies	>1 publications with SytVI and Adenocarcinoma
Brain Diseases Antibodies	>1 publications with SytVI and Brain Diseases
Kidney Diseases Antibodies	>1 publications with SytVI and Kidney Diseases

Organs/Tissues associated with anti-SytVI antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>7 publications with SytVI and Brain
Kidney Antibodies	>1 publications with SytVI and Kidney