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SCN2B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS418322

Scn2b (Sodium channel beta-2 subunit) is crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The beta-2 subunit causes an increase in the plasma membrane surface area and in its folding into… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
Scn2b (Sodium channel beta-2 subunit), Polyclonal Antibody
Full Product Name
Anti-Scn2b (Sodium channel beta-2 subunit) Antibody
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Form/Format
Liquid
Purity/Purification
Purified by antigen-specific affinity chromatography.
Concentration
1ug/ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
24,326 Da
OMIM
AF007783 mRNA
3D Structure
ModBase 3D Structure for O60939
Immunogen
Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of rat Scn2b (Sodium channel beta-2 subunit)
Storage Buffer
PBS, pH 7.4 with 0.05% sodium azide.
Applications Tested/Suitable for anti-Scn2b antibody
Western Blot (WB), ELISA (EIA)

Product References and Citations for anti-Scn2b antibody

Isom, L.L. al et, Cell 83 (3), 433-442 (1995) Srinivasan, J., et al, Proc. Natl. Acad. Sci. U.S.A. 95 (26), 15753-15757 (1998) Vijayaragavan, K., et al, Biochem. Biophys. Res. Commun. 319 (2),531-540 (2004)

Other Notes

Small volumes of anti-Scn2b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Scn2b purchase

MBS418322 is an antibody targeting Scn2b. Also known as Anti-Scn2b (Sodium channel beta-2 subunit) Antibody. Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Scn2b. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
sodium channel subunit beta-2
NCBI Official Synonym Full Names
sodium voltage-gated channel beta subunit 2
NCBI Official Symbol
SCN2B
NCBI Official Synonym Symbols
ATFB14
UniProt Protein Name
Sodium channel subunit beta-2
Protein Family
UniProt Gene Name
SCN2B
NCBI Protein Information
sodium channel subunit beta-2

NCBI Summary for Scn2b

The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015]
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UniProt Comments for Scn2b

SCN2B: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: voltage-gated sodium channel complex

Molecular Function: sodium channel regulator activity

Biological Process: cardiac muscle contraction; synaptic transmission

Disease: Atrial Fibrillation, Familial, 14
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Scn2b antibody

 Reference Product  PubMed Publications
 SCN1B antibody  >16 publications with Scn2b and SCN1B

Organs/Tissues associated with anti-Scn2b antibody

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