SLFN2 Antibody – Rabbit Polyclonal

The Schlafen (Slfn) family of genes are differentially regulated during thymocyte maturation and are preferentially expressed in the lymphoid tissues. Ectopic expression of the prototype member Slfn1 early in the T lineage profoundly alters cell growth and development. In these mice, the DP thymocytes fail to complete maturation, and, depending on the transgene dosage, the number of thymocytes is reduced to 1%-30% of normal. Furthermore, expression of the Schlafen family members in fibroblasts and thymoma cells either retards or ablates cell growth. The conceptual protein sequences deduced for each of the family members have no similarity to characterized proteins and must therefore participate in a heretofore unknown regulatory mechanism guiding both cell growth and T cell development.

Schwarz, D.A., et al, Immunity 9 (5), 657-668 (1998) Cohen-Tannoudji, M., et al, Genomics 68 (3), 273-282 (2000)

Small volumes of anti-SLFN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS418327 is an antibody targeting SLFN2. Also known as Anti-SLFN2/SLFN3 (schlafen 2/schlafen 3) Antibody. Reactive in Mouse. Host: Rabbit.