hBUBR1 Antibody – Mouse Monoclonal

The BUB family of serine/threonine kinases is a major target of oncology therapeutic research and development. hBUB1 and hBUBR1 are kinases that associate with hBUB3 and are essential components of the mitotic checkpoint. hBUBR1 appears to provide two checkpoint functions by monitoring CENP-E-dependent activities at the kinetochore and by regulating cyclosome/APC activity.hBUBR1 is required in order for microtubule inhibitors to arrest cells in mitosis. Non-mutational inactivation of hBUB1 and hBUBR1 appear related to stage of colon cancer and could be related to aneuploidy in human colorectal and other cancers.

Chan GK, Jablonski SA, et al. "Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC, " J Cell Biol Sept 1999;146 (5):941-54 [PMID: 10477750]

Small volumes of anti-hBUBR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS418470 is an antibody targeting hBUBR1. Reactive in Human. Host: Mouse.