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CENTD3 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS418871

MBS418871 is an antibody targeting CENTD3. Also known as Anti-CENTD3 / ARAP3 Antibody. Reactive in Human. Host: Goat. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CENTD3 / ARAP3, Polyclonal Antibody
Full Product Name
Anti-CENTD3 / ARAP3 Antibody
Product Gene Name
anti-CENTD3 antibody
Product Synonym Gene Name
ARAP3
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
Affinity Purified
Concentration
100ug/200ul (lot specific)
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Molecular Weight
94,043 Da
Immunogen
CTSSPPSSQPLT
Storage Buffer
Supplied at 0.5 mg/ml in Tris saline,0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Applications Tested/Suitable for anti-CENTD3 antibody
Western Blot (WB), ELISA (EIA)

Other Notes

Small volumes of anti-CENTD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CENTD3. It may not necessarily be applicable to this product.

NCBI GI #
156865862
NCBI GeneID
106952
NCBI Accession #
ABU96464.1
UniProt Secondary Accession #
Q5DTN4; Q6NVF1; Q8R5G6; E9QMK7
UniProt Related Accession #
Q8R5G7
NCBI Official Full Name
Centd3, partial
NCBI Official Synonym Full Names
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
NCBI Official Symbol
Arap3
NCBI Official Synonym Symbols
Drag1; Centd3; cnt-d3; E030006K04Rik
UniProt Protein Name
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
UniProt Synonym Protein Names
Centaurin-delta-3; Cnt-d3; Dual specificity Rho- and Arf-GTPase-activating protein 1
UniProt Gene Name
Arap3
UniProt Synonym Gene Names
Centd3; Drag1; Kiaa4097; Cnt-d3
NCBI Protein Information
arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

NCBI Summary for CENTD3

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
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UniProt Comments for CENTD3

ARAP3: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts on ARF6, RAC1, RHOA and CDC42. Plays a role in the internalization of anthrax toxin.

Protein type: GAPs; GAPs, ARF; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 18|18 B3

Cellular Component: cytoplasm; lamellipodium; ruffle

Molecular Function: GTPase activator activity; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding

Biological Process: negative regulation of cell migration; negative regulation of Rac protein signal transduction; negative regulation of Rho protein signal transduction; regulation of cell shape
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Research Articles on CENTD3

1. Deletion of Arap3 in osteoblasts and mesenchymal stromal cells using Prx1-Cre resulted in no discernable phenotypes in hematopoietic development or hematopoietic stem cells homeostasis in adult mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CENTD3 antibody

 Reference Product  PubMed Publications
 Rhoa antibody  >17 publications with CENTD3 and Rhoa
 Cdc42 antibody  >2 publications with CENTD3 and Cdc42
 Vav2 antibody  >1 publications with CENTD3 and Vav2

Pathways associated with anti-CENTD3 antibody

 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rap1 Signaling Pathway antibodies  Rap1 Signaling Pathway Diagram
 Rho GTPase Cycle Pathway antibodies  Rho GTPase Cycle Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Rho GTPases Pathway antibodies  Signaling By Rho GTPases Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram

Diseases associated with anti-CENTD3 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with CENTD3 and Inflammation
 Disease Models, Animal Antibodies  >2 publications with CENTD3 and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >2 publications with CENTD3 and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >2 publications with CENTD3 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >1 publications with CENTD3 and Cardiovascular Diseases
 Lung Injury Antibodies  >1 publications with CENTD3 and Lung Injury
 Neoplasm Invasiveness Antibodies  >1 publications with CENTD3 and Neoplasm Invasiveness
 Adenocarcinoma Antibodies  >1 publications with CENTD3 and Adenocarcinoma
 Fibrosis Antibodies  >1 publications with CENTD3 and Fibrosis
 Respiratory Tract Diseases Antibodies  >1 publications with CENTD3 and Respiratory Tract Diseases

Organs/Tissues associated with anti-CENTD3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with CENTD3 and Blood
 Bone Marrow Antibodies  >2 publications with CENTD3 and Bone Marrow
 Lung Antibodies  >1 publications with CENTD3 and Lung
 Pancreas Antibodies  >1 publications with CENTD3 and Pancreas
 Thyroid Antibodies  >1 publications with CENTD3 and Thyroid
 Brain Antibodies  >1 publications with CENTD3 and Brain
 Embryonic Tissue Antibodies  >1 publications with CENTD3 and Embryonic Tissue
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