BMP7 Antibody – Rabbit Polyclonal

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]

BMP7: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; protein binding; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; cardiac muscle development; dendrite development; epithelial to mesenchymal transition; hindbrain development; inhibition of NF-kappaB transcription factor; mesenchymal cell differentiation; mesonephros development; metanephros development; negative regulation of cell cycle; negative regulation of MAP kinase activity; negative regulation of mitosis; negative regulation of neuron differentiation; negative regulation of NF-kappaB import into nucleus; negative regulation of phosphorylation; negative regulation of transcription, DNA-dependent; neural fold elevation formation; neurite morphogenesis; pharyngeal system development; positive regulation of bone mineralization; positive regulation of heterotypic cell-cell adhesion; positive regulation of osteoblast differentiation; positive regulation of transcription, DNA-dependent; regulation of apoptosis; skeletal development; steroid hormone mediated signaling; ureteric bud development