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PPP3CA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS419517

MBS419517 is an antibody targeting PPP3CA. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
PPP3CA, Polyclonal Antibody
Full Product Name
Anti-PPP3CA Antibody
Product Gene Name
anti-PPP3CA antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Specificity
Western blot analysis of extracts of various cell lines, using PPP3CA antibody. Immunohistochemistry of paraffin-embedded human lung cancer using PPP3CA antibody at dilution of 1:200 (400x lens). Immunohistochemistry of paraffin-embedded human stomach cancer using PPP3CA antibody at dilution of 1:200 (400x lens). Immunofluorescence analysis of HeLa cell using PPP3CA antibody. Blue: DAPI for nuclear staining.
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
51,245 Da
OMIM
L14778 mRNA
Immunogen
Recombinant protein of human PPP3CA
Storage Buffer
PBS with 0.02% sodium azide,50% glycerol, pH7.3.
Applications Tested/Suitable for anti-PPP3CA antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-PPP3CA antibody
WB: 1:500 - 1:2000
IHC: 1:50- 1:200
IF: 1:50- 1:200

Western Blot (WB) of anti-PPP3CA antibody

Rabbit Anti-PPP3CA Polyclonal Antibody – Cat# MBS419517

Immunohistochemistry (IHC) of anti-PPP3CA antibody

Rabbit Anti-PPP3CA Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS419517

Immunohistochemistry (IHC) of anti-PPP3CA antibody

Rabbit Anti-PPP3CA Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS419517

Immunofluorescence (IF) of anti-PPP3CA antibody

Rabbit Anti-PPP3CA Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS419517

Other Notes

Small volumes of anti-PPP3CA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PPP3CA. It may not necessarily be applicable to this product.

NCBI GI #
19343933
NCBI GeneID
5530
NCBI Accession #
AAH25714.1
UniProt Secondary Accession #
Q8TAW9; A1A441; A8K3B7; A8W6Z7; A8W6Z8; B5BUA2
UniProt Related Accession #
Q08209
NCBI Official Full Name
PPP3CA protein
NCBI Official Synonym Full Names
protein phosphatase 3 catalytic subunit alpha
NCBI Official Symbol
PPP3CA
NCBI Official Synonym Symbols
CALN; CCN1; CNA1; CALNA; PPP2B; CALNA1
UniProt Protein Name
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
UniProt Synonym Protein Names
CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform
Protein Family
Serine/threonine-protein phosphatase
UniProt Gene Name
PPP3CA
UniProt Synonym Gene Names
CALNA; CNA
NCBI Protein Information
serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

UniProt Comments for PPP3CA

PPP3CA: a calmodulin-dependent Ser/Thr phosphatase also known calcineurin A alpha. Involved in a wide range of biologic activities, acting as a Ca(2 )-dependent modifier of phosphorylation status. Dephosphorylates HSPB1. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. .

Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: calcineurin complex; cytoplasm; cytosol; nucleoplasm

Molecular Function: calmodulin binding; calmodulin-dependent protein phosphatase activity; drug binding; enzyme binding; protein binding; protein dimerization activity

Biological Process: calcineurin-NFAT signaling pathway; dephosphorylation; positive regulation of NFAT protein import into nucleus; positive regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation; response to calcium ion; T cell activation; Wnt receptor signaling pathway, calcium modulating pathway
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Research Articles on PPP3CA

1. CN-A and nephrin were clearly reduced in the kidneys of a 10-year-old boy who had relapsing steroid-resistant nephrotic syndrome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PPP3CA antibody

 Reference Product  PubMed Publications
 PPP3R1 antibody  >7 publications with PPP3CA and PPP3R1
 NFATC1 antibody  >2 publications with PPP3CA and NFATC1

Pathways associated with anti-PPP3CA antibody

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 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
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 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
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 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram

Diseases associated with anti-PPP3CA antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with PPP3CA and Neoplasms
 Nervous System Diseases Antibodies  >3 publications with PPP3CA and Nervous System Diseases
 Hypertrophy Antibodies  >3 publications with PPP3CA and Hypertrophy
 Brain Diseases Antibodies  >3 publications with PPP3CA and Brain Diseases
 Inflammation Antibodies  >2 publications with PPP3CA and Inflammation
 Abnormalities, Drug-Induced Antibodies  >1 publications with PPP3CA and Abnormalities, Drug-Induced
 Edema Antibodies  >1 publications with PPP3CA and Edema
 Liver Diseases Antibodies  >1 publications with PPP3CA and Liver Diseases
 Necrosis Antibodies  >1 publications with PPP3CA and Necrosis
 Testicular Diseases Antibodies  >1 publications with PPP3CA and Testicular Diseases

Organs/Tissues associated with anti-PPP3CA antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >9 publications with PPP3CA and Muscle
 Heart Antibodies  >5 publications with PPP3CA and Heart
 Blood Antibodies  >5 publications with PPP3CA and Blood
 Brain Antibodies  >5 publications with PPP3CA and Brain
 Vascular Antibodies  >4 publications with PPP3CA and Vascular
 Bone Antibodies  >2 publications with PPP3CA and Bone
 Eye Antibodies  >1 publications with PPP3CA and Eye
 Kidney Antibodies  >1 publications with PPP3CA and Kidney
 Mammary Gland Antibodies  >1 publications with PPP3CA and Mammary Gland
 Lung Antibodies  >1 publications with PPP3CA and Lung
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