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RAB5A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS419587

Rab5 is a member of the Ras superfamily of small Rab GTPases. Rab5 is localized at the plasma membrane and early endosomes and functions as a key regulator of vesicular trafficking during early endocytosis (1). The conformational change between Rab5 GTP/GDP… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
RAB5A, Polyclonal Antibody
Full Product Name
Anti-RAB5A Antibody
Product Gene Name
anti-RAB5A antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Specificity
Western blot analysis of extracts of various cell lines, using RAB5A antibody. Immunofluorescence analysis of HeLa cell using RAB5A antibody. Blue: DAPI for nuclear staining.
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
22,178 Da
OMIM
M28215 mRNA
Immunogen
Recombinant protein of human RAB5A
Storage Buffer
PBS with 0.02% sodium azide,50% glycerol, pH7.3.
Applications Tested/Suitable for anti-RAB5A antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-RAB5A antibody
WB: 1:500 - 1:2000
IHC: 1:50- 1:200
IF: 1:50- 1:200

Western Blot (WB) of anti-RAB5A antibody

Rabbit Anti-RAB5A Polyclonal Antibody – Cat# MBS419587

Immunofluorescence (IF) of anti-RAB5A antibody

Rabbit Anti-RAB5A Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS419587

Other Notes

Small volumes of anti-RAB5A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RAB5A purchase

MBS419587 is an antibody targeting RAB5A. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RAB5A. It may not necessarily be applicable to this product.

NCBI GI #
49168472
NCBI GeneID
5868
NCBI Accession #
CAG38731.1
UniProt Secondary Accession #
Q6FI44; B4DJA5
UniProt Related Accession #
P20339
NCBI Official Full Name
RAB5A
NCBI Official Synonym Full Names
RAB5A, member RAS oncogene family
NCBI Official Symbol
RAB5A
NCBI Official Synonym Symbols
RAB5
UniProt Protein Name
Ras-related protein Rab-5A
Protein Family
Ras-related protein
UniProt Gene Name
RAB5A
UniProt Synonym Gene Names
RAB5
NCBI Protein Information
ras-related protein Rab-5A

UniProt Comments for RAB5A

RAB5A: Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Binds EEA1. Interacts with RIN1 and GAPVD1, which regulate its pathway, probably by acting as a GEF. Interacts with ALS2CL, RABEP1, SUN2, ZFYVE20 and RUFY1. Interacts with SGSM1 and SGSM3. Interacts with PIK3CB. Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Belongs to the small GTPase superfamily. Rab family.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p24.3

Cellular Component: axon; cell soma; cytoplasm; cytosol; dendrite; early endosome; endocytic vesicle; endosome; endosome membrane; nerve terminal; plasma membrane; synaptic vesicle; terminal button

Molecular Function: GDP binding; GTP binding; GTPase activity; protein binding

Biological Process: blood coagulation; early endosome to late endosome transport; endocytosis; positive regulation of exocytosis; regulation of endocytosis; regulation of endosome size; regulation of filopodium formation
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Research Articles on RAB5A

1. TTBK2 down-regulates GluK2 activity by decreasing the receptor protein abundance in the cell membrane via RAB5-dependent endocytosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RAB5A antibody

 Reference Product  PubMed Publications
 EEA1 antibody  >12 publications with RAB5A and EEA1
 RIN1 antibody  >5 publications with RAB5A and RIN1
 CFTR antibody  >2 publications with RAB5A and CFTR
 ALS2 antibody  >1 publications with RAB5A and ALS2
 ZFYVE20 antibody  >1 publications with RAB5A and ZFYVE20
 RABEP1 antibody  >1 publications with RAB5A and RABEP1

Pathways associated with anti-RAB5A antibody

 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram

Diseases associated with anti-RAB5A antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >22 publications with RAB5A and Neoplasms
 Carcinoma Antibodies  >11 publications with RAB5A and Carcinoma
 Inflammation Antibodies  >8 publications with RAB5A and Inflammation
 Death Antibodies  >5 publications with RAB5A and Death
 Brain Diseases Antibodies  >3 publications with RAB5A and Brain Diseases
 Pain Antibodies  >2 publications with RAB5A and Pain
 Fibrosis Antibodies  >2 publications with RAB5A and Fibrosis
 Weight Loss Antibodies  >2 publications with RAB5A and Weight Loss
 Carcinoma, Hepatocellular Antibodies  >2 publications with RAB5A and Carcinoma, Hepatocellular
 Ovarian Neoplasms Antibodies  >1 publications with RAB5A and Ovarian Neoplasms

Organs/Tissues associated with anti-RAB5A antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with RAB5A and Brain
 Kidney Antibodies  >16 publications with RAB5A and Kidney
 Lung Antibodies  >13 publications with RAB5A and Lung
 Blood Antibodies  >11 publications with RAB5A and Blood
 Nerve Antibodies  >9 publications with RAB5A and Nerve
 Vascular Antibodies  >7 publications with RAB5A and Vascular
 Heart Antibodies  >6 publications with RAB5A and Heart
 Liver Antibodies  >6 publications with RAB5A and Liver
 Muscle Antibodies  >5 publications with RAB5A and Muscle
 Placenta Antibodies  >5 publications with RAB5A and Placenta
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