FGF10 Antibody – Rabbit Polyclonal

FGF10: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Belongs to the heparin-binding growth factors family.

Protein type: Cell development/differentiation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5p12

Cellular Component: cell surface; extracellular matrix; extracellular region; extracellular space; nucleus; plasma membrane

Molecular Function: 1-phosphatidylinositol-3-kinase activity; chemoattractant activity; fibroblast growth factor receptor binding; growth factor activity; heparin binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; type 2 fibroblast growth factor receptor binding

Biological Process: actin cytoskeleton reorganization; activation of MAPK activity; branching morphogenesis of a tube; epithelial cell proliferation; fibroblast growth factor receptor signaling pathway; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; lacrimal gland development; MAPKKK cascade; mesonephros development; metanephros development; phosphoinositide-mediated signaling; positive chemotaxis; positive regulation of ATPase activity; positive regulation of DNA repair; positive regulation of DNA replication; positive regulation of epithelial cell proliferation; positive regulation of keratinocyte migration; positive regulation of lymphocyte proliferation; positive regulation of MAPKKK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of transcription, DNA-dependent; positive regulation of urothelial cell proliferation; radial glial cell differentiation; regulation of phosphoinositide 3-kinase cascade; regulation of saliva secretion; salivary gland development; thymus development; urothelial cell proliferation; wound healing

Disease: Aplasia Of Lacrimal And Salivary Glands; Lacrimoauriculodentodigital Syndrome