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MITF Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS419640

This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment… More details

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Product Overview

Product Name
MITF, Polyclonal Antibody
Full Product Name
Anti-MITF Antibody
Product Gene Name
anti-MITF antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Specificity
Western blot analysis of extracts of various cell lines, using MITF antibody.
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
52,527 Da
OMIM
AB006909 mRNA
Immunogen
Recombinant protein of human MITF
Storage Buffer
PBS with 0.02% sodium azide,50% glycerol, pH7.3.
Applications Tested/Suitable for anti-MITF antibody
Western Blot (WB)
Application Notes for anti-MITF antibody
WB: 1:500 - 1:2000

Western Blot (WB) of anti-MITF antibody

Rabbit Anti-MITF Polyclonal Antibody – Cat# MBS419640

Other Notes

Small volumes of anti-MITF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MITF purchase

MBS419640 is an antibody targeting MITF. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MITF. It may not necessarily be applicable to this product.

NCBI GI #
823671950
NCBI GeneID
4286
NCBI Accession #
AKI71186.1
UniProt Secondary Accession #
Q14841; Q9P2V0; Q9P2V1; Q9P2V2; Q9P2Y8; B4DJL2; D3K197; E9PFN0
UniProt Related Accession #
O75030
NCBI Official Full Name
MITF, partial
NCBI Official Synonym Full Names
melanogenesis associated transcription factor
NCBI Official Symbol
MITF
NCBI Official Synonym Symbols
MI; WS2; CMM8; WS2A; COMMAD; bHLHe32
UniProt Protein Name
Microphthalmia-associated transcription factor
UniProt Synonym Protein Names
Class E basic helix-loop-helix protein 32; bHLHe32
Protein Family
Microphthalmia-associated transcription factor
UniProt Gene Name
MITF
UniProt Synonym Gene Names
BHLHE32; bHLHe32
NCBI Protein Information
microphthalmia-associated transcription factor

UniProt Comments for MITF

MITF: a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. Plays a critical role in the differentiation of various cell types including neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. Two isoforms are known: the M-isoform is expressed exclusively in melanocytes, while the A-isoform has a much broader range of expression. Mutations in MITF can lead to Waardenburg syndrome. Ten alternatively spliced isoforms have been described.

Protein type: DNA-binding; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 3p13

Cellular Component: nucleoplasm; protein complex

Molecular Function: protein binding

Biological Process: melanocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein complex assembly; protein sumoylation

Disease: Albinism, Ocular, With Sensorineural Deafness; Melanoma, Cutaneous Malignant, Susceptibility To, 8; Tietz Syndrome; Waardenburg Syndrome, Type 2a
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Research Articles on MITF

1. Our studies have established that the cooperative antiproliferative effects of aspirin and I3C in human melanoma cells trigger a significant downregulation of MITF-M gene expression and disruption of MITF-M promoter activity. results demonstrate that aspirin-regulated Wnt signaling and I3C-targeted signaling pathways converge at distinct DNA elements in the MITF-M promoter to cooperatively disrupt MITF-M expression
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MITF antibody

 Reference Product  PubMed Publications
 SOX10 antibody  >129 publications with MITF and SOX10
 PAX3 antibody  >115 publications with MITF and PAX3
 CTNNB1 antibody  >98 publications with MITF and CTNNB1
 PAX6 antibody  >39 publications with MITF and PAX6
 PMEL antibody  >33 publications with MITF and PMEL
 CREB1 antibody  >22 publications with MITF and CREB1
 LEF1 antibody  >16 publications with MITF and LEF1
 MAPK14 antibody  >2 publications with MITF and MAPK14
 EP300 antibody  >2 publications with MITF and EP300

Pathways associated with anti-MITF antibody

 Products by Pathway  Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 Melanoma Pathway antibodies  Melanoma Pathway Diagram
 Melanoma Pathway antibodies  Melanoma Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram

Diseases associated with anti-MITF antibody

 Disease Name  Pubmed Publications
 Melanoma Antibodies  >979 publications with MITF and Melanoma
 Neoplasms, Experimental Antibodies  >171 publications with MITF and Neoplasms, Experimental
 Pigmentation Disorders Antibodies  >154 publications with MITF and Pigmentation Disorders
 Deafness Antibodies  >74 publications with MITF and Deafness
 Carcinoma, Renal Cell Antibodies  >55 publications with MITF and Carcinoma, Renal Cell
 Inflammation Antibodies  >55 publications with MITF and Inflammation
 Kidney Diseases Antibodies  >54 publications with MITF and Kidney Diseases
 Neoplasm Invasiveness Antibodies  >43 publications with MITF and Neoplasm Invasiveness
 Waardenburg syndrome type 2 Antibodies  >38 publications with MITF and Waardenburg syndrome type 2
 Necrosis Antibodies  >36 publications with MITF and Necrosis

Organs/Tissues associated with anti-MITF antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >708 publications with MITF and Skin
 Eye Antibodies  >226 publications with MITF and Eye
 Blood Antibodies  >155 publications with MITF and Blood
 Bone Antibodies  >143 publications with MITF and Bone
 Muscle Antibodies  >77 publications with MITF and Muscle
 Embryonic Tissue Antibodies  >71 publications with MITF and Embryonic Tissue
 Kidney Antibodies  >67 publications with MITF and Kidney
 Brain Antibodies  >50 publications with MITF and Brain
 Lung Antibodies  >41 publications with MITF and Lung
 Ear Antibodies  >40 publications with MITF and Ear
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