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CASP7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS419684

Caspase-7 (CMH-1, Mch3, ICE-LAP3) has been identified as a major contributor to the execution of apoptosis (1-4). Caspase-7, like caspase-3, is an effector caspase that is responsible for cleaving downstream substrates such as (ADP-ribose) polymerase and PARP… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CASP7, Polyclonal Antibody
Full Product Name
Anti-CASP7 Antibody
Product Gene Name
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Specificity
Western blot analysis of extracts of various cell lines, using CASP7 antibody. Immunohistochemistry of paraffin-embedded human stomach cancer using CASP7 antibody at dilution of 1:200 (400x lens).
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Molecular Weight
31,614 Da
OMIM
U37448 mRNA
3D Structure
ModBase 3D Structure for P55210
Immunogen
Recombinant protein of human CASP7
Storage Buffer
PBS with 0.02% sodium azide,50% glycerol, pH7.3.
Applications Tested/Suitable for anti-CASP7 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-CASP7 antibody
WB: 1:500 - 1:2000
IHC: 1:50- 1:200
ICC: 1:50- 1:100
IP: 1:50- 1:100

Western Blot (WB) of anti-CASP7 antibody

Rabbit Anti-CASP7 Polyclonal Antibody – Cat# MBS419684

Immunohistochemistry (IHC) of anti-CASP7 antibody

Rabbit Anti-CASP7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS419684

Other Notes

Small volumes of anti-CASP7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CASP7 purchase

MBS419684 is an antibody targeting CASP7. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CASP7. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
caspase-7 isoform g
NCBI Official Synonym Full Names
caspase 7
NCBI Official Symbol
CASP7
NCBI Official Synonym Symbols
MCH3; CMH-1; LICE2; CASP-7; ICE-LAP3
UniProt Protein Name
Caspase-7
UniProt Synonym Protein Names
Apoptotic protease Mch-3; CMH-1; ICE-like apoptotic protease 3; ICE-LAP3
Protein Family
UniProt Gene Name
CASP7
UniProt Synonym Gene Names
MCH3; CASP-7; ICE-LAP3
NCBI Protein Information
caspase-7

NCBI Summary for CASP7

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
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UniProt Comments for CASP7

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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