BIRC5 Antibody – Rabbit Polyclonal

Survivin: an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. Associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. May play a role in neoplasia. Inhibitor of caspase-3 and caspase-7. Two splice variant isoforms have been described.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: chromosome, pericentric region; cytoplasm; cytosol; midbody; nuclear chromosome; nucleoplasm; nucleus

Molecular Function: chaperone binding; enzyme binding; identical protein binding; microtubule binding; protein binding; Ran GTPase binding; ubiquitin-protein ligase activity

Biological Process: negative regulation of apoptosis; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; protein amino acid phosphorylation; protein complex localization; protein sumoylation; regulation of apoptosis; regulation of signal transduction; sister chromatid cohesion